CD28 and CD27 costimulation of CD8+ T cells: a story of survival.

CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Research Abstract Details 

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CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Abstract Text:

Douglas V Dolfi,Peter D Katsikis,

Although the requirement of CD28 and CD27 costimulation has been clearly demonstrated during primary CD8+ T cell responses and this costimulation acts by providing proliferation and survival cues to naive CD8+ T cells, a number of questions also arise from these studies. Is the requirement for CD28 and CD27 costimulation restricted to the initiation of the immune response in the lymph nodes, where presumably the initial contact between naive CD8+ T cell and DC occurs? What is the purpose of the dramatic influx of DC to sites of inflammation such as the lung during influenza virus infection and the formation of inflammatory BALT (iBALT)?(104) Are such DC at the site of inflammation and at later stages of the immune response providing cytokines or costimulation to effector CD8+ T cells? If DC are required for optimal secondary responses (100), is CD28 costimulation the missing signal or is it other members of the B7:CD28 family or TNF family? Given that a number of investigators are actively addressing these questions, the answers we expect will be soon to come and open exciting new opportunities for immune enhancement or dampening strategies and vaccine adjuvants.

CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Publishing Authors By Initials

DV Dolfi,PD Katsikis,

For similar virus diseases research abstracts see: virus diseases research

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MEDLINE DATE:

CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Journal Published:

PUBLICATION TYPE: Review

Journal: Advances in experimental medicine and biology

VOLUME: 590

Page Numbers: 149-70

Journal Abbreviation: Adv. Exp. Med. Biol.

ISSN: 0065-2598

DAY: 3

MONTH: 12

YEAR: 2007

CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Information

Number of References: 104

LANGUAGE: eng

NlmUniqueID: 121103

CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: immunology

Chemical & Substance for Abstract: CD28 and CD27 costimulation of CD8+ T cells: a story of survival. Information

Substance Name: Lymphocyte Specific Protein Tyrosine Kin

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for CD28 and CD27 costimulation of CD8+ T cells: a story of survival.

AFFILIATION: Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI66215

ACRONYM: AI

MEDLINETA: Adv Exp Med Biol

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