CD22 Regulates Time Course of Both B Cell Division and Antibody Response.

CD22 Regulates Time Course of Both B Cell Division and Antibody Response. Research Abstract Details 

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CD22 Regulates Time Course of Both B Cell Division and Antibody Response. Abstract Text:

Taishi Onodera,Jonathan C Poe,Thomas F Tedder,Takeshi Tsubata,Taishi Onodera,Jonathan C Poe,Thomas F Tedder,Takeshi Tsubata,

Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."

CD22 Regulates Time Course of Both B Cell Division and Antibody Response. Publishing Authors By Initials

T Onodera,JC Poe,TF Tedder,T Tsubata,T Onodera,JC Poe,TF Tedder,T Tsubata,

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CD22 Regulates Time Course of Both B Cell Division and Antibody Response. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 180

Page Numbers: 907-13

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Jan

YEAR: 2008

CD22 Regulates Time Course of Both B Cell Division and Antibody Response. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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AFFILIATION: Laboratory of Immunology, School of Biomedical Science, and.

Country: United States

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MEDLINETA: J Immunol

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