CD19 expression in B cells is important for suppression of contact hypersensitivity.

CD19 expression in B cells is important for suppression of contact hypersensitivity. Research Abstract Details 

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CD19 expression in B cells is important for suppression of contact hypersensitivity. Abstract Text:

Rei Watanabe,Manabu Fujimoto,Nobuko Ishiura,Yoshihiro Kuwano,Hiroko Nakashima,Norihito Yazawa,Hitoshi Okochi,Shinichi Sato,Thomas F Tedder,Kunihiko Tamaki,

Contact hypersensitivity (CHS) is a cutaneous immune reaction mediated mainly by antigen-specific effector T cells and is regarded as a model for Th1/Tc1-mediated inflammation. However, recent reports have suggested pivotal roles of B cells in CHS. CD19 serves as a positive B-cell response regulator that defines signaling thresholds critical for B-cell responses. In the current study, we assessed the role of the B-cell-specific surface molecule CD19 on the development of CHS by examining CD19-deficient mice. Although CD19-deficient mice are hyposensitive to a variety of transmembrane signals, CD19 loss resulted in increased and prolonged reaction of CHS, suggesting an inhibitory role of CD19 expression in CHS. Sensitized lymph nodes and elicited ear lesions from CD19-deficient mice exhibited Th1/Tc1-shifted cytokine profile with increased interferon-gamma expression and decreased interleukin-10 expression. Adoptive transfer experiments revealed that CD19 expression in recipient mice was required for optimal suppression of CHS response, indicating its role in the elicitation phase. Furthermore, spleen B cells, especially marginal zone B cells, from wild-type mice were able to normalize exaggerated CHS reactions in CD19-deficient mice. Thus, CD19 expression in B cells is critical for termination of CHS responses, possibly through the function of regulatory B cells.

CD19 expression in B cells is important for suppression of contact hypersensitivity. Publishing Authors By Initials

R Watanabe,M Fujimoto,N Ishiura,Y Kuwano,H Nakashima,N Yazawa,H Okochi,S Sato,TF Tedder,K Tamaki,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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CD19 expression in B cells is important for suppression of contact hypersensitivity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of pathology

VOLUME: 171

Page Numbers: 560-70

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 7

MONTH: 06

YEAR: 2007

CD19 expression in B cells is important for suppression of contact hypersensitivity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

CD19 expression in B cells is important for suppression of contact hypersensitivity. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: pathology

Chemical & Substance for Abstract: CD19 expression in B cells is important for suppression of contact hypersensitivity. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for CD19 expression in B cells is important for suppression of contact hypersensitivity.

AFFILIATION: Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Country: United States

AGENCY: United States NCI

GRANT: CA96547

ACRONYM: CA

MEDLINETA: Am J Pathol

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