CD147 immunoglobulin superfamily receptor function and role in pathology.

CD147 immunoglobulin superfamily receptor function and role in pathology. Research Abstract Details 

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CD147 immunoglobulin superfamily receptor function and role in pathology. Abstract Text:

Kathryn T Iacono,Amy L Brown,Mark I Greene,Sandra J Saouaf,Kathryn T Iacono,Amy L Brown,Mark I Greene,Sandra J Saouaf,Kathryn T Iacono,Amy L Brown,Mark I Greene,Sandra J Saouaf,

The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced.

CD147 immunoglobulin superfamily receptor function and role in pathology. Publishing Authors By Initials

KT Iacono,AL Brown,MI Greene,SJ Saouaf,KT Iacono,AL Brown,MI Greene,SJ Saouaf,KT Iacono,AL Brown,MI Greene,SJ Saouaf,

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CD147 immunoglobulin superfamily receptor function and role in pathology. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental and molecular pathology

VOLUME: 83

Page Numbers: 283-95

Journal Abbreviation: Exp. Mol. Pathol.

ISSN: 0014-4800

DAY: 7

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 370711

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Grant and Affiliation Information for CD147 immunoglobulin superfamily receptor function and role in pathology.

AFFILIATION: University of Pennsylvania, Department of Pathology and Laboratory Medicine, 252 John Morgan Building, 36th & Hamilton Walk, Philadelphia, PA 19104-6082, USA.

Country: United States

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MEDLINETA: Exp Mol Pathol

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