CCR7 signaling inhibits T cell proliferation.

CCR7 signaling inhibits T cell proliferation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

CCR7 signaling inhibits T cell proliferation. Abstract Text:

Ekkehard Ziegler,Martin Oberbarnscheidt,Silvia Bulfone-Paus,Reinhold ,Ulrich Kunzendorf,Stefan Krautwald,Ekkehard Ziegler,Martin Oberbarnscheidt,Silvia Bulfone-Paus,Reinhold ,Ulrich Kunzendorf,Stefan Krautwald,

CCR7 and its ligands, CCL19 and CCL21, are responsible for directing the migration of T cells and dendritic cells into lymph nodes, where these cells play an important role in the initiation of the immune response. Recently, we have shown that systemic application of CCL19-IgG is able to inhibit the colocalization of T cells and dendritic cells within secondary lymphoid organs, resulting in pronounced immunosuppression with reduced allograft rejection after organ transplantation. In this study, we demonstrate that the application of sustained high concentrations of either soluble or immobilized CCL19 and CCL21 elicits an inhibitory program in T cells. We show that these ligands specifically interfere with cell proliferation and IL-2 secretion of CCR7(+) cells. This could be demonstrated for human and murine T cells and was valid for both CD4(+) and CD8(+) T cells. In contrast, CCL19 had no inhibitory effect on T cells from CCR7 knockout mice, but CCR7(-/-) T cells showed a proliferative response upon TCR-stimulation similar to that of CCL19-treated wild-type cells. Furthermore, the inhibition of proliferation is associated with delayed degradation of the cyclin-dependent kinase (CDK) inhibitor p27(Kip1) and the down-regulation of CDK1. This shows that CCR7 signaling is linked to cell cycle control and that sustained engagement of CCR7, either by high concentrations of soluble ligands or by high density of immobilized ligands, is capable of inducing cell cycle arrest in TCR-stimulated cells. Thus, CCR7, a chemokine receptor that has been demonstrated to play an essential role during activation of the immune response, is also competent to directly inhibit T cell proliferation.

CCR7 signaling inhibits T cell proliferation. Publishing Authors By Initials

E Ziegler,M Oberbarnscheidt,S Bulfone-Paus,R ,U Kunzendorf,S Krautwald,E Ziegler,M Oberbarnscheidt,S Bulfone-Paus,R ,U Kunzendorf,S Krautwald,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

CCR7 signaling inhibits T cell proliferation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 6485-93

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Nov

YEAR: 2007

CCR7 signaling inhibits T cell proliferation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

CCR7 signaling inhibits T cell proliferation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: CCR7 signaling inhibits T cell proliferation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for CCR7 signaling inhibits T cell proliferation.

AFFILIATION: Department of Nephrology and Hypertension, University of Kiel, Kiel, Germany.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

CCR7 signaling inhibits T cell proliferation Related Publications

• CCR7 signaling inhibits T cell proliferation.
• [Not Available.]
• [Value of rectal administration of dextrose.]
• [Viral etiology of a disease accompanied by hepatitis and feather disorders in budgerigar fledgelings (Melopsittacus undulatus)]