CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer.

CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer. Research Abstract Details 

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CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer. Abstract Text:

Hidefumi Sasaki,Katsuhiro Okuda,Katsuhiko Endo,Osamu Kawano,Haruhiro Yukiue,Tomoki Yokoyama,Motoki Yano,Yoshitaka Fujii,Hidefumi Sasaki,Katsuhiro Okuda,Katsuhiko Endo,Osamu Kawano,Haruhiro Yukiue,Tomoki Yokoyama,Motoki Yano,Yoshitaka Fujii,Hidefumi Sasaki,Katsuhiro Okuda,Katsuhiko Endo,Osamu Kawano,Haruhiro Yukiue,Tomoki Yokoyama,Motoki Yano,Yoshitaka Fujii,

BACKGROUND: Epidermal growth factor receptor (EGFR) stimulation markedly increases cyclin D1 protein expression. Recently, it has been reported that cyclin D1 expression was increased in EGFR mutant cell lines; however, the expression status of CCND1 in EGFR mutant lung cancer tissues has not been reported. PATIENTS AND METHODS: We have investigated the CCND1 messenger RNA (mRNA) levels and other clinicopathologic data in 74 lung cancers. The CCND1 mRNA levels were quantified by real-time reverse-transcriptase polymerase chain reaction using LightCycler. RESULTS: The CCND1/GAPDH mRNA levels were significantly higher in adenocarcinoma (35.125 +/- 37.387) than in non-adenocarcinoma (15.2 +/- 24.699; P = .0158), and CCND1/GAPDH mRNA levels were not significantly different among smoking status, sex, or pathologic stage. The CCND1/GAPDH mRNA levels were significantly higher in lung cancer with EGFR mutation (39.713 +/- 41.265) than in lung cancer without EGFR mutation (21.805 +/- 29.152; P = .0338). CCND/GAPDH mRNA expression did not correlate with prognosis of lung cancer. CONCLUSION: Using the LightCycler real-time reverse-transcriptase polymerase chain reaction assay, CCND1 gene expression might correlate with EGFR mutation in lung cancer. However, further studies are needed to confirm the impact of cyclin D1 for a molecular target of lung cancer.

CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer. Publishing Authors By Initials

H Sasaki,K Okuda,K Endo,O Kawano,H Yukiue,T Yokoyama,M Yano,Y Fujii,H Sasaki,K Okuda,K Endo,O Kawano,H Yukiue,T Yokoyama,M Yano,Y Fujii,H Sasaki,K Okuda,K Endo,O Kawano,H Yukiue,T Yokoyama,M Yano,Y Fujii,

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CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical lung cancer

VOLUME: 8

Page Numbers: 493-6

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ISSN: 1525-7304

DAY: 9

MONTH: Sep

YEAR: 2007

CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer. Information

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LANGUAGE: eng

NlmUniqueID: 100893225

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Grant and Affiliation Information for CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer.

AFFILIATION: Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan. hisasaki@med.nagoya-cu.ac.jp

Country: United States

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MEDLINETA: Clin Lung Cancer

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