Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates.

Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Research Abstract Details 

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Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Abstract Text:

Laura A Flashman,Robert M Roth,Heather S Pixley,Howard B Cleavinger,Thomas W McAllister,Robert Vidaver,Andrew J Saykin,

Increased frequency of cavum septum pellucidum (CSP) has been inconsistently observed in schizophrenia, and little is known about its functional implications. We investigated whether patients with schizophrenia were more likely than healthy controls to have CSP, and among patients assessed the relationship between CSP, psychiatric symptoms, and selected neuropsychological functions. Seventy-seven patients with diagnoses of DSM-IV schizophrenia spectrum disorders and 55 healthy controls were studied and completed a 1.5 T MRI scan. Two raters, blind to group membership, determined the presence, length and grade of the CSP. A subset of participants also underwent neuropsychological testing. A CSP of at least 1 mm in length was present in 68.8% of patients and 76.4% of controls, and the groups did not differ significantly with respect to presence or absence, length, overall size, or percent with an abnormally large CSP (> or =6 mm). Patients with an abnormally large CSP demonstrated poorer performance on measures of verbal learning and memory than patients with smaller CSP. Among patients, CSP length was significantly correlated with negative symptoms, verbal learning, and sentence comprehension. Among patients with abnormally large CSP, CSP length was correlated with reaction time on two conditions of a Continuous Performance Test. CSP, while prevalent, was not more frequent in our sample of patients with schizophrenia, and had few associations with symptom severity or neuropsychological deficits.

Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Publishing Authors By Initials

LA Flashman,RM Roth,HS Pixley,HB Cleavinger,TW McAllister,R Vidaver,AJ Saykin,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 154

Page Numbers: 147-55

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ISSN: 0165-1781

DAY: 7

MONTH: 02

YEAR: 2007

Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: pathology

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Grant and Affiliation Information for Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates.

AFFILIATION: Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, and New Hampshire Hospital, Lebanon, NH, USA. Laura.A.Flashman@Dartmouth.Edu

Country: Ireland

AGENCY: United States NIBIB

GRANT: U54 EB005149-01

ACRONYM: EB

MEDLINETA: Psychiatry Res

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