Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient.

Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Research Abstract Details 

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Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Abstract Text:

Virginie Santilman,JoAnne Baran,Bela Anand-Apte,Paul L Fox,Marie-Odile Parat,

Polarization is a hallmark of migrating cells, and an asymmetric distribution of proteins is essential to the migration process. Caveolin-1 is highly polarized in migrating endothelial cells (EC). Several studies have shown caveolin-1 accumulation in the front of migrating EC while others report its accumulation in the EC rear. In this paper we address these conflicting results on polarized localization of caveolin-1. We find evidence for the hypothesis that different modes of locomotion lead to differences in protein polarization. In particular, we show that caveolin-1 is primarily localized in the rear of cells migrating on a planar substrate, but in the front of cells traversing a three-dimensional pore. We also show that a chemoattractant, present either as a gradient or ubiquitously in the medium, does not alter caveolin-1 localization in cells in either mode of locomotion. Thus we conclude that substrate topology, and not the presence of a chemoattractant, directs the polarization of caveolin-1 in motile ECs.

Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Publishing Authors By Initials

V Santilman,J Baran,B Anand-Apte,PL Fox,MO Parat,

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Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell motility and the cytoskeleton

VOLUME: 63

Page Numbers: 673-80

Journal Abbreviation: Cell Motil. Cytoskeleton

ISSN: 0886-1544

DAY: 3

MONTH: Nov

YEAR: 2006

Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Information

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LANGUAGE: eng

NlmUniqueID: 8605339

Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Information

Substance Name: Vascular Endothelial Growth Factors

Registry Number: 0

Grant and Affiliation Information for Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient.

AFFILIATION: Department of Anesthesiology Research, Cleveland Clinic, Cleveland, Ohio 44195, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL75255

ACRONYM: HL

MEDLINETA: Cell Motil Cytoskeleton

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