Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth.

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Research Abstract Details 

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Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Abstract Text:

Michelle I Lin,Jun Yu,Takahisa Murata,William C Sessa,

Caveolin-1 (Cav-1) is a major structural protein that is essential to the formation of the organelle, caveolae. Cav-1 knockout (KO) mice were observed to be completely devoid of caveolae yet they exhibit a hyperpermeable vasculature. Given the nature of the hyperpermeable Cav-1 KO endothelium, we sought to investigate if tumors grown in Cav-1 KO mice would be leaky and grow faster. Indeed, Lewis lung carcinoma cells implanted into Cav-1 KO mice had increased tumor vascular permeability, measured by Evans blue extravasation and fibrinogen deposition compared with tumors implanted into wild-type (WT) mice. Cav-1 KO mice also had significantly higher tumor growth rates, attributable to increased tumor angiogenesis and decreased tumor cell death. Furthermore, administration of an antipermeability peptide, cavtratin, was able to correct the tumor hyperpermeability as well as attenuate the increased tumor growth. Mechanistically, endothelial cells isolated from Cav-1 KO mice exhibited increased tyrosine phosphorylation on vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) and decreased association with the adherens junction protein, VE-cadherin. Thus, the loss of Cav-1 increases tumor permeability and growth and that may relate to enhanced VEGF signaling due to lack of Cav-1 inhibition of VEGFR-2 or decreased VE-cadherin mediated VEGFR-2 phosphorylation.

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Publishing Authors By Initials

MI Lin,J Yu,T Murata,WC Sessa,

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Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 67

Page Numbers: 2849-56

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Mar

YEAR: 2007

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor Recep

MESH TERMS: metabolism

Chemical & Substance for Abstract: Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Information

Substance Name: Vascular Endothelial Growth Factor Recep

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth.

AFFILIATION: Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL 64793

ACRONYM: HL

MEDLINETA: Cancer Res

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