Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Research Abstract Details 

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Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Abstract Text:

Xiao Mei Wang,Yingze Zhang,Hong Pyo Kim,Zhihong Zhou,Carol A Feghali-Bostwick,Fang Liu,Emeka Ifedigbo,Xiaohui Xu,Tim D Oury,Naftali Kaminski,Augustine M K Choi,

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by activation of fibroblasts and overproduction of extracellular matrix (ECM). Caveolin-1 (cav-1), a principal component of caveolae, has been implicated in the regulation of numerous signaling pathways and biological processes. We observed marked reduction of cav-1 expression in lung tissues and in primary pulmonary fibroblasts from IPF patients compared with controls. We also demonstrated that cav-1 markedly ameliorated bleomycin (BLM)-induced pulmonary fibrosis, as indicated by histological analysis, hydroxyproline content, and immunoblot analysis. Additionally, transforming growth factor beta1 (TGF-beta1), the well-known profibrotic cytokine, decreased cav-1 expression in human pulmonary fibroblasts. cav-1 was able to suppress TGF-beta1-induced ECM production in cultured fibroblasts through the regulation of the c-Jun N-terminal kinase (JNK) pathway. Interestingly, highly activated JNK was detected in IPF- and BLM-instilled lung tissue samples, which was dramatically suppressed by ad-cav-1 infection. Moreover, JNK1-null fibroblasts showed reduced smad signaling cascades, mimicking the effects of cav-1. This study indicates a pivotal role for cav-1 in ECM regulation and suggests a novel therapeutic target for patients with pulmonary fibrosis.

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Publishing Authors By Initials

XM Wang,Y Zhang,HP Kim,Z Zhou,CA Feghali-Bostwick,F Liu,E Ifedigbo,X Xu,TD Oury,N Kaminski,AM Choi,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research

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MEDLINE DATE:

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 203

Page Numbers: 2895-906

Journal Abbreviation: J. Exp. Med.

ISSN: 0022-1007

DAY: 18

MONTH: 12

YEAR: 2006

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985109

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta1

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. Information

Substance Name: Mitogen-Activated Protein Kinase 8

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.

AFFILIATION: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL55330

ACRONYM: HL

MEDLINETA: J Exp Med

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