Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine.

Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine. Research Abstract Details 

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Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine. Abstract Text:

E Saccardo,P Novati,D Sironi,L Castelnovo,G Rinaldi,G Monti,

Cryoglobulinemic Syn&come (CS) is a multi-systemic disease, and its fatal evolution can involve different organs. Aims: To describe the most frequent causes of death in CS, by researching different evolutions between older cases and those of the last 15 years. Patients: The data of 238 patients affected by symptomatic cryoglobulinemia followed by our Medicine Department in the last 30 years are recorded in a database. 54 are presently living and being followed, 70 (36F, 34M) have died. The type II/type III ratio is 5/4. We distinguish between two groups, the oldest, without any data on HCV, and the most recent who were tested for HCV. The follow-up ranges from 0.5 to 16 years. Results: Liver diseases (25 cases, 9 with hepatic carcinomas), lymphomas and myeloproliferative diseases (12), and cardiovascular events (8) are the most reported causes of death. Sepsis, neurological syndromes, nephropathy, other malignancies and diffuse vasculitis are also reported. The median age at death was 67.2 years (58.4 in the oldest group, 71.9 in the other). Hepatic carcinomas are reported only after 1991. Conclusion: Cirrhosis complications are more frequent in patients affected by HCV. The increase in instrumental diagnostic ability and the improved survival of patients with cirrhosis account for the increase in patients with hepatic carcinomas. Improved treatment has resulted in a reduction of deaths from renal failure.

Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine. Publishing Authors By Initials

E Saccardo,P Novati,D Sironi,L Castelnovo,G Rinaldi,G Monti,

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Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Digestive and liver disease : official journal of

VOLUME: 39 Suppl 1

Page Numbers: S52-4

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ISSN: 1590-8658

DAY: 15

MONTH: Sep

YEAR: 2007

Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Causes of death in symptomatic cryoglobulinemia: 30 years of observation in a Department of Internal Medicine.

AFFILIATION: Internal Medicine Unit, Saronno Hospital, Azienda Ospedaliera di Busto Arsizio, Saronno, VA, Italy.

Country: Netherlands

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MEDLINETA: Dig Liver Dis

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