Causal inference for non-mortality outcomes in the presence of death.

Causal inference for non-mortality outcomes in the presence of death. Research Abstract Details 

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Causal inference for non-mortality outcomes in the presence of death. Abstract Text:

Brian L Egleston,Daniel O Scharfstein,Ellen E Freeman,Sheila K West,

Evaluation of the causal effect of a baseline exposure on a morbidity outcome at a fixed time point is often complicated when study participants die before morbidity outcomes are measured. In this setting, the causal effect is only well defined for the principal stratum of subjects who would live regardless of the exposure. Motivated by gerontologic researchers interested in understanding the causal effect of vision loss on emotional distress in a population with a high mortality rate, we investigate the effect among those who would live both with and without vision loss. Since this subpopulation is not readily identifiable from the data and vision loss is not randomized, we introduce a set of scientifically driven assumptions to identify the causal effect. Since these assumptions are not empirically verifiable, we embed our methodology within a sensitivity analysis framework. We apply our method using the first three rounds of survey data from the Salisbury Eye Evaluation, a population-based cohort study of older adults. We also present a simulation study that validates our method.

Causal inference for non-mortality outcomes in the presence of death. Publishing Authors By Initials

BL Egleston,DO Scharfstein,EE Freeman,SK West,

For similar nervous system diseases: neurologic manifestations: sensation disorders: vision disorders research abstracts see: nervous system diseases: neurologic manifestations: sensation disorders: vision disorders research

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Causal inference for non-mortality outcomes in the presence of death. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biostatistics (Oxford, England)

VOLUME: 8

Page Numbers: 526-45

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ISSN: 1465-4644

DAY: 15

MONTH: 09

YEAR: 2006

Causal inference for non-mortality outcomes in the presence of death. Information

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LANGUAGE: eng

NlmUniqueID: 100897327

Causal inference for non-mortality outcomes in the presence of death. Keywords Mesh Terms:

KEYWORDS: Vision Disorders

MESH TERMS: psychology

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Grant and Affiliation Information for Causal inference for non-mortality outcomes in the presence of death.

AFFILIATION: Biostatistics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Brian.Egleston@fccc.edu

Country: England

AGENCY: United States NIA

GRANT: T32 AG00247

ACRONYM: AG

MEDLINETA: Biostatistics

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