Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex.

Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Research Abstract Details 

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Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Abstract Text:

T Klockgether,M Schwarz,L Turski,K H Sontag,

To investigate the behavioural role of mesocortical dopamine innervation we performed bilateral microinjections of haloperidol into various parts of the rat frontal cortex and into adjacent subcortical forebrain structures. Haloperidol (2.5 micrograms/0.5 microliter) locally injected into the medial prefrontal cortex or into the rostral part of the neostriatum resulted in the development of catalepsy as measured in the bar test. In contrast, injections of haloperidol into the nucleus accumbens, more caudal parts of the neostriatum, anterior cingulate cortex, rostral and lateral parts of the prefrontal cortex and into the lateral ventricles failed to induce catalepsy. It is concluded that blockade of dopamine receptors located in the rostral neostriatum and in the medial prefrontal cortex contributes to the development of haloperidol induced catalepsy.

Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Publishing Authors By Initials

T Klockgether,M Schwarz,L Turski,KH Sontag,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 70

Page Numbers: 445-7

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1988

Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex. Information

Substance Name: Haloperidol

Registry Number: 52-86-8

Grant and Affiliation Information for Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex.

AFFILIATION: Max-Planck-Institute for Experimental Medicine, Göttingen, Federal Republic of Germany.

Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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