Catalase deficiency may complicate urate oxidase (rasburicase) therapy.

Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Research Abstract Details 

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Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Abstract Text:

,N William Bigler,

Patients with low (inherited and acquired) catalase activities who are treated with infusion of uric acid oxidase because they are at risk of tumour lysis syndrome may experience very high concentrations of hydrogen peroxide. They may suffer from methemoglobinaemia and haemolytic anaemia which may be attributed either to deficiency of glucose-6-phosphate dehydrogenase or to other unknown circumstances. Data have not been reported from catalase deficient patients who were treated with uric acid oxidase. It may be hypothesized that their decreased blood catalase could lead to the increased concentration of hydrogen peroxide which may cause haemolysis and formation of methemoglobin. Blood catalase activity should be measured for patients at risk of tumour lysis syndrome prior to uric acid oxidase treatment.

Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Publishing Authors By Initials

L ,NW Bigler,

For similar enzymes and coenzymes: enzymes: oxidoreductases: urate oxidase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: urate oxidase research

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Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Free radical research

VOLUME: 41

Page Numbers: 953-5

Journal Abbreviation: Free Radic. Res.

ISSN: 1071-5762

DAY: 27

MONTH: Sep

YEAR: 2007

Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Information

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LANGUAGE: eng

NlmUniqueID: 9423872

Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Keywords Mesh Terms:

KEYWORDS: Urate Oxidase

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Information

Substance Name: rasburicase

Registry Number: EC 1.7.3.3.

Grant and Affiliation Information for Catalase deficiency may complicate urate oxidase (rasburicase) therapy.

AFFILIATION: Department of Clinical Biochemistry, Molecular Pathology and Clinical Analytical Chemistry, Medical College, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. goth@dote.hu

Country: England

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MEDLINETA: Free Radic Res

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