Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis.

Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Research Abstract Details 

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Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Abstract Text:

Melanie A Samuel,John D Morrey,Michael S Diamond,

West Nile virus (WNV) is a neurotropic, arthropod-borne flavivirus that has become a significant global cause of viral encephalitis. To examine the mechanisms of WNV-induced neuronal death and the importance of apoptosis in pathogenesis, we evaluated the role of a key apoptotic regulator, caspase 3. WNV infection induced caspase 3 activation and apoptosis in the brains of wild-type mice. Notably, congenic caspase 3(-/-) mice were more resistant to lethal WNV infection, although there were no significant differences in the tissue viral burdens or the kinetics of viral spread. Instead, decreased neuronal death was observed in the cerebral cortices, brain stems, and cerebella of caspase 3(-/-) mice. Analogously, primary central nervous system (CNS)-derived neurons demonstrated caspase 3 activation and apoptosis after WNV infection, and treatment with caspase inhibitors or a genetic deficiency in caspase 3 significantly decreased virus-induced death. These studies establish that caspase 3-dependent apoptosis contributes to the pathogenesis of lethal WNV encephalitis and suggest possible novel therapeutic targets to restrict CNS injury.

Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Publishing Authors By Initials

MA Samuel,JD Morrey,MS Diamond,

For similar viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research abstracts see: viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research

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Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 2614-23

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 27

MONTH: 12

YEAR: 2006

Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Keywords Mesh Terms:

KEYWORDS: West Nile virus

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. Information

Substance Name: Caspase 3

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis.

AFFILIATION: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 53870

ACRONYM: AI

MEDLINETA: J Virol

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