Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment.

Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment. Research Abstract Details 

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Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment. Abstract Text:

Soo Ryang Kim,Susumu Imoto,Shuichi Fuki,Miyuki Taniguchi,Ke Ih Kim,Keiji Mita,Kenji Ando,Taisuke Nakajima,Hyun Soo Hong,Katsumi Fukuda,Noriko Sasase,Masatoshi Kudo,Yoshitake Hayashi,

Here we report the case of a 48-year-old man, carrier of genotype C HBV for longer than 6 months after contracting sexually transmitted acute hepatitis B, who eventually lost HBsAg and acquired HBsAb by IFN/lamivudine therapy. The patient had been negative for HBsAg in 2001, but, during his stay in China from January to July in 2003, he developed acute hepatitis B after having an extra-marital sexual contact there. HBsAg was still positive and a liver biopsy indicated chronic hepatitis when he was admitted to our hospital in December 2003 for detailed examination of liver dysfunction. HBV DNA in his serum, revealed to segregate to genotype C by sequencing on admission, decreased to undetectable levels at the end of a 3-month IFN therapy, and remained undetectable during and after the successive 6-month lamivudine therapy. HBeAg seroconverted to HBeAb during the therapy, and HBsAb appeared after the therapy. To our knowledge, this is the first case of genotype C chronic hepatitis B occurring after acute hepatitis.

Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment. Publishing Authors By Initials

SR Kim,S Imoto,S Fuki,M Taniguchi,KI Kim,K Mita,K Ando,T Nakajima,HS Hong,K Fukuda,N Sasase,M Kudo,Y Hayashi,

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Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 36

Page Numbers: 149-52

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 1

MONTH: 08

YEAR: 2006

Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment. Information

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LANGUAGE: eng

NlmUniqueID: 9711801

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Grant and Affiliation Information for Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment.

AFFILIATION: Department of Gastroenterology, Kobe Asahi Hospital, 3-5-25 Bouoji-cho, Nagata-ku, Kobe 653-0801, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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