Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review.

Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Research Abstract Details 

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Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Abstract Text:

J Tehranzadeh,F Booya,J Root,

Osteoarthritis (O.A.) is the most common type of articular disease. This is an idiopathic joint disease characterized by an imbalance between synthesis and degradation of articular cartilage and subchondral bone accompanied by capsular fibrosis, osteophyte formation and variable grade of inflammation of synovial membrane. Joint lubrication is naturally provided by Hyaluronic acid in syovial fluid. Hyaluronan is present in abundance in normal young and healthy joints. In degenerative O.A. Hyaluronan is smaller in size, molecular weight and diminished in concentration. This decrease in joint lubrication and shock absorbing mechanism in O.A. can be remedied by intraarticular viscosupplementation. Alternatively the pain and secondary inflammation in O.A. can be relieved by intraarticular injection of steroids and long acting local anesthetics. Promt and effective reduction in local inflammation occurs after intra-articular injection of corticosteriod. This article reviews the cartilage metabolism in O.A., discusses the pros and cons of these treatments and provides a literature review of the studies which compare benefits and adverse reactions of viscosupplementation vs. intraarticular steroids with placebo treatment.

Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Publishing Authors By Initials

J Tehranzadeh,F Booya,J Root,

For similar natural sciences: chemistry: chemistry, physical: viscosity research abstracts see: natural sciences: chemistry: chemistry, physical: viscosity research

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Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta radiologica (Stockholm, Sweden : 1987)

VOLUME: 46

Page Numbers: 288-96

Journal Abbreviation:

ISSN: 0284-1851

DAY: 1

MONTH: May

YEAR: 2005

Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 8706123

Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Keywords Mesh Terms:

KEYWORDS: Viscosity

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Information

Substance Name: Hyaluronic Acid

Registry Number: 9004-61-9

Grant and Affiliation Information for Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review.

AFFILIATION: Department of Radiological Sciences, University of California, Irvine, California, USA. jtehranz@uci.edu

Country: Sweden

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MEDLINETA: Acta Radiol

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