Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet.

Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Research Abstract Details 

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Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Abstract Text:

Isidore C Okere,Margaret P Chandler,Tracy A McElfresh,Julie H Rennison,Theodore A Kung,Brian D Hoit,Paul Ernsberger,Martin E Young,William C Stanley,

1. Cardiac lipotoxicity is characterized by hypertrophy and contractile dysfunction and can be triggered by impaired mitochondrial fatty acid oxidation and lipid accumulation. The present study investigated the effect of dietary fatty acid intake alone and in combination with inhibition of mitochondrial fatty acid uptake with the carnitine palmitoyl transferase (CPT)-I inhibitor oxfenicine. Long-chain fatty acids activate peroxisome proliferator-activated receptors (PPAR), thus mRNA levels of PPAR target genes were measured. 2. Rats were untreated or given the CPT-I inhibitor oxfenicine (150 mg/kg per day) and were fed for 8 weeks with either: (i) standard low-fat chow (10% of energy from fat); (ii) a long-chain saturated fatty acid diet; (iii) a long-chain unsaturated fatty acid diet; or (iv) a medium-chain fatty acid diet (which bypasses CPT-I). High-fat diets contained 60% of energy from fat. 3. Cardiac triglyceride content was increased in the absence of oxfenicine in the saturated fat group compared with other diets. Oxfenicine treatment further increased cardiac triglyceride stores in the saturated fat group and caused a significant increase in the unsaturated fat group. Despite elevations in triglyceride stores, left ventricular mass, end diastolic volume and systolic function were unaffected. 4. The mRNA levels of PPAR-regulated genes were increased by the high saturated and unsaturated fat diets compared with standard chow or the medium chain fatty acid chow. Oxfenicine did not further upregulate PPARalpha target genes within each dietary treatment group. 5. Taken together, the data suggest that consuming a high-fat diet or inhibiting CPT-I do not result in cardiac hypertrophy or cardiac dysfunction in normal rats.

Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Publishing Authors By Initials

IC Okere,MP Chandler,TA McElfresh,JH Rennison,TA Kung,BD Hoit,P Ernsberger,ME Young,WC Stanley,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

PUBMED ID PMID:

MEDLINE DATE: 2007 Jan-Feb

Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical and experimental pharmacology & physiolog

VOLUME: 34

Page Numbers: 113-9

Journal Abbreviation: Clin. Exp. Pharmacol. Physiol.

ISSN: 0305-1870

DAY: 3

MONTH: 12

YEAR: 2007

Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 425076

Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: blood

Chemical & Substance for Abstract: Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet. Information

Substance Name: Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet.

AFFILIATION: Department of Physiology, Case Western Reserve University, Cleveland, Ohio 44106-4970, USA.

Country: Australia

AGENCY: United States NHLBI

GRANT: HL074237

ACRONYM: HL

MEDLINETA: Clin Exp Pharmacol Physiol

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