Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial.

Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Research Abstract Details 

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Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Abstract Text:

Keith Norris,Jacque Bourgoigne,Jennifer Gassman,Lee Hebert,John Middleton,Robert A Phillips,Otelio Randall,Stephen Rostand,Susan Sherer,Robert D Toto,Jackson T Wright,Xuelei Wang,Tom Greene,Lawrence J Appel,Julia Lewis, ,

BACKGROUND: Patients with chronic kidney disease are at increased risk for cardiovascular (CV) events. METHODS: We randomly assigned 1,094 African Americans with hypertensive nephrosclerosis (glomerular filtration rate [GFR], 20 to 65 mL/min/1.73 m(2) [0.33 to 1.08 mL/s]) to initial antihypertensive treatment with either: (1) a beta-blocker, metoprolol; (2) an angiotensin-converting enzyme inhibitor, ramipril; or (3) a dihydropyridine calcium channel blocker, amlodipine, and either a usual-blood pressure (BP) or low-BP treatment goal. Using a design powered to detect renal outcome differences, we compared the effect of treatment on the CV event rate (cardiac death, myocardial infarction, stroke, and heart failure) during a mean follow-up period of 4.1 years and determined baseline factors that predict CV outcomes. RESULTS: Thirty-one patients died of CV disease (0.7%/patient-year), and 149 patients experienced at least 1 CV outcome (3.3%/patient-year). Overall, 202 CV events (4.5%/patient-year) occurred. The CV outcome rate was not related significantly to randomized interventions. In multivariable analyses, 7 baseline risk factors remained independently associated with increased risk for the CV composite outcome after controlling for age, sex, baseline GFR, and baseline proteinuria group: pulse pressure, duration of hypertension, abnormal electrocardiogram result, non-high-density lipoprotein cholesterol level, serum urea nitrogen level, urine protein-creatinine ratio, urine sodium-potassium ratio, and annual income less than 15,000 dollars. CONCLUSION: Neither randomized class of antihypertensive therapy nor BP level had a significant effect on the occurrence of CV events, possibly because of limited power. However, this analysis identifies unique and potentially modifiable CV risk factors in this high-risk cohort.

Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Publishing Authors By Initials

K Norris,J Bourgoigne,J Gassman,L Hebert,J Middleton,RA Phillips,O Randall,S Rostand,S Sherer,RD Toto,JT Wright,X Wang,T Greene,LJ Appel,J Lewis, ,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of kidney diseases : the official

VOLUME: 48

Page Numbers: 739-51

Journal Abbreviation: Am. J. Kidney Dis.

ISSN: 1523-6838

DAY: 3

MONTH: Nov

YEAR: 2006

Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8110075

Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: etiology

Chemical & Substance for Abstract: Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial.

AFFILIATION: Charles R. Drew University of Medicine and Science, Lynwood, CA 90262, USA. knorris@ucla.edu

Country: United States

AGENCY: United States NCRR

GRANT: P20-RR11145

ACRONYM: RR

MEDLINETA: Am J Kidney Dis

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