Cardiovascular effects of nickel in ambient air.

Cardiovascular effects of nickel in ambient air. Research Abstract Details 

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Cardiovascular effects of nickel in ambient air. Abstract Text:

Michael D Dutton,

BACKGROUND: Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease in susceptible populations. OBJECTIVE: Our objective in this study was to determine the most influential FPM components. METHODS: A mouse model of atherosclerosis (ApoE-/-) was exposed to either filtered air or concentrated FPM (CAPs) in Tuxedo, New York (85 microg/m3 average, 6 hr/day, 5 days/week, for 6 months), and the FPM elemental composition was determined for each day. We also examined associations between PM components and mortality for two population studies: National Mortality and Morbidity Air Pollution Study (NMMAPS) and Hong Kong. RESULTS: For the CAPs-exposed mice, the average of nickel was 43 ng/m3, but on 14 days, there were Ni peaks at approximately 175 ng/m3 and unusually low FPM and vanadium. For those days, back-trajectory analyses identified a remote Ni point source. Electrocardiographic measurements on CAPs-exposed and sham-exposed mice showed Ni to be significantly associated with acute changes in heart rate and its variability. In NMMAPS, daily mortality rates in the 60 cities with recent speciation data were significantly associated with average Ni and V, but not with other measured species. Also, the Hong Kong sulfur intervention produced sharp drops in sulfur dioxide, Ni, and V, but not other components, corresponding to the intervention-related reduction in cardiovascular and pulmonary mortality. CONCLUSIONS: Known biological mechanisms cannot account for the significant associations between Ni with the acute cardiac function changes in the mice or with cardiovascular mortality in people at low ambient air concentrations; therefore, further research is needed.

Cardiovascular effects of nickel in ambient air. Publishing Authors By Initials

MD Dutton,

For similar complex mixtures: particulate matter research abstracts see: complex mixtures: particulate matter research

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Cardiovascular effects of nickel in ambient air. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Environmental health perspectives

VOLUME: 114

Page Numbers: 1662-9

Journal Abbreviation: Environ. Health Perspect.

ISSN: 0091-6765

DAY: 3

MONTH: Nov

YEAR: 2006

Cardiovascular effects of nickel in ambient air. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 330411

Cardiovascular effects of nickel in ambient air. Keywords Mesh Terms:

KEYWORDS: Particulate Matter

MESH TERMS: toxicity

Chemical & Substance for Abstract: Cardiovascular effects of nickel in ambient air. Information

Substance Name: Nickel

Registry Number: 7440-02-0

Grant and Affiliation Information for Cardiovascular effects of nickel in ambient air.

AFFILIATION: New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, New York 10987, USA. lippmann@env.med.nyu.edu

Country: United States

AGENCY: United States NIEHS

GRANT: ES00260

ACRONYM: ES

MEDLINETA: Environ Health Perspect

REFSOURCE: Environ Health Perspect. 2007 Jun;115(6)

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