[Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.]

[Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.] Research Abstract Details 

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[Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.] Abstract Text:

F Ferreri,C Agbokou,S Gauthier,F Ferreri,C Agbokou,S Gauthier,F Ferreri,C Agbokou,S Gauthier,F Ferreri,C Agbokou,S Gauthier,

Introduction. In the treatment of mild to moderate Alzheimer's disease, cholinesterase inhibitors (ChEIs) have shown modest clinical benefits. State of the art. Use of donepezil, galantamine and rivastigmine is widespread in clinical practice. Although relatively safe, ChEIs are prescribed for a frail population and may have clinically significant adverse drug effects on the cardiovascular system. Arrhythmia and syncope have been reported. Most of the cardiovascular adverse drug reactions to ChEIs might be related to stimulation of the parasympatic nervous system. Perspectives. Early and accurate recognition of past and present arrhythmia or syncope appears to be essential. Monitoring for pharmacokinetic (cytochromes P450 CYP2D6 or CYP3A4) and pharmacodynamic interactions and a more systematic clinical follow-up are mandatory. In patients with relevant risk factors or with cardiovascular adverse drug reactions a multidisciplinary approach with a cardiologist is required. CONCLUSION: Prevention of cardiac adverse events requires a careful clinical evaluation before the introduction of the ChEIs and an early recognition of cardiac disturbances under treatment.

[Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.] Publishing Authors By Initials

F Ferreri,C Agbokou,S Gauthier,F Ferreri,C Agbokou,S Gauthier,F Ferreri,C Agbokou,S Gauthier,F Ferreri,C Agbokou,S Gauthier,

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[Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Revue neurologique

VOLUME: 163

Page Numbers: 968-74

Journal Abbreviation: Rev. Neurol. (Paris)

ISSN: 0035-3787

DAY: 22

MONTH: Oct

YEAR: 2007

[Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.] Information

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LANGUAGE: fre

NlmUniqueID: 2984779

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Grant and Affiliation Information for [Cardiovascular effects of cholinesterase inhibitors in Alzheimer's disease.]

AFFILIATION: Unité de recherche sur la maladie d'Alzheimer, centre McGill d'études sur le vieillissement, Montréal, Canada.

Country: France

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MEDLINETA: Rev Neurol (Paris)

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