Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams.

Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Research Abstract Details 

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Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Abstract Text:

A E Jimenez,J C Passmore,

We reported that the pups of one kidney:one-clip Goldblatt hypertensive (HT) rats have a predisposition to the induction of experimental hypertension. To investigate the nature of the predisposition, pups of HT dams were challenged with vasopressor agents at 28-days-of-age or treated with DOCA and 6.5% salt diet between 35 and 81 days-of-age. Pups of HT dams had a significantly greater blood pressure between 28 and 81 days-of-age and also showed a greater change in blood pressure when provided a 6.5% salt diet than did pups of normotensive dams. Pups of HT dams demonstrated a decreased bradycardic response after injection of angiotensin II (p less than .05) and a lesser change in mean arterial blood pressure after injection of angiotensin II or norepinephrine than did the pups from normotensive dams. These results suggest an effect of maternal hypertension on the development of cardiovascular control mechanisms in her offspring. The decreased pressor response suggests the predisposition is not due to an increased vascular sensitivity to vasopressors.

Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Publishing Authors By Initials

AE Jimenez,JC Passmore,

For similar inorganic chemicals: sodium compounds: sodium, dietary research abstracts see: inorganic chemicals: sodium compounds: sodium, dietary research

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Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 12

Page Numbers: 227-41

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1990

Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Keywords Mesh Terms:

KEYWORDS: Sodium, Dietary

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams. Information

Substance Name: Desoxycorticosterone

Registry Number: 64-85-7

Grant and Affiliation Information for Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams.

AFFILIATION: Department of Physiology and Biophysics School of Medicine, University of Louisville, KY 40292.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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