Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events.

Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Research Abstract Details 

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Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Abstract Text:

All major randomized trials that have tested the effectiveness of antihypertensive therapy have exclusively or almost exclusively been based on mortality and morbidity data (fatal and non-fatal strokes, fatal and non-fatal myocardial infarctions, sudden cardiac deaths, cardiovascular mortality, mortality by any cause). Thus, trials based on the monitoring of events have succeeded in ascertaining the achievement of the most important goals of treatment of any morbid condition--the prolongation of life and prevention of incapacitating morbid events. However, a clear distinction has to be made between cardiovascular events, as measured in any randomized trial of antihypertensive therapy, and the underlying vascular lesions, which have never been measured in large randomized therapeutic trials. Therefore, the results of therapeutic trials based on events cannot be applied towards the conclusion that antihypertensive therapy has similar effects on the underlying disease. Indeed, the mechanisms responsible for the precipitation of events are often different from the mechanisms leading to disease. Both the prevention of cardiovascular events and prevention of organ damage or disease are essential goals of antihypertensive therapy. As the mechanisms leading to vascular injury and to events are, to a significant extent, different, the achievement of the two goals has to be evaluated through trials that use, separately or conjointly, different criteria--either cardiovascular events, or one or more measures of cardiovascular injury. Trials based on cardiovascular injury are now possible due to the relatively large number of quantitatively precise and reproducible techniques for evaluating organ damage accompanying hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: clinical trials as topic: controlled clinical trials as topic: randomized controlled trials as topic research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: clinical trials as topic: controlled clinical trials as topic: randomized controlled trials as topic research

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Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood pressure. Supplement

VOLUME: 1

Page Numbers: 1-4

Journal Abbreviation:

ISSN: 0803-8023

DAY: 26

MONTH: 02

YEAR: 1994

Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Information

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LANGUAGE: eng

NlmUniqueID: 9300787

Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Keywords Mesh Terms:

KEYWORDS: Randomized Controlled Trials as Topic

MESH TERMS: therapy

Chemical & Substance for Abstract: Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events. Information

Substance Name: Antihypertensive Agents

Registry Number: 0

Grant and Affiliation Information for Cardiovascular consequences of hypertension: therapeutic effects on organ damage and on cardiovascular events.

AFFILIATION: Institute of Clinical Medicine and Therapeutics, University of Milan, Italy.

Country: NORWAY

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MEDLINETA: Blood Press Suppl

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