Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts.

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Abstract Text:

Tomoyuki Ohno,Naohiko Kobayashi,Kohtaro Yoshida,Hiromichi Fukushima,Hiroaki Matsuoka,Tomoyuki Ohno,Naohiko Kobayashi,Kohtaro Yoshida,Hiromichi Fukushima,Hiroaki Matsuoka,

BackgroundWe have known that endothelial nitric-oxide synthase (eNOS) and oxidative stress may play a key role in cardiac performance in failing rat hearts. However, the interactions between eNOS or oxidative stress and bradykinin (BK) under treatment of calcium channel blockers (CCBs) remain unknown. To elucidate the mechanism underlying the cardioprotective effect of long-acting dihydropyridine CCBs, we evaluated the effect of benidipine on the BK-eNOS and NAD(P)H oxidase pathway in Dahl salt-sensitive (DS) rats with heart failure.Methods11-week-old DS rats were treated with one of the following drug combinations for 7 weeks until the onset of the failing stage: vehicle, BK B2 receptor antagonist (FR172357 (FR)) alone, hydralazine, benidipine, and benidipine plus FR. The left ventricular end-systolic pressure-volume relationship (ESPVR) (contractility: Ees) was evaluated using a conductance catheter.ResultsDownregulated Ees and per cent of fractional shortening (%FS) assessed by echocardiography and eNOS expression in the failing stage were both significantly increased by using benidipine; this result was not found, however, when using FR alone or hydralazine or benidipine plus FR. Upregulated expression of NAD(P)H oxidase p22phox and p47phox and lectin-like oxidized low-density lipoprotein receptor-1, and downregulated superoxide dismutase-1 (SOD-1) were significantly ameliorated by benidipine, but not by FR alone or by hydralazine or benidipine plus FR. Benidipine effectively inhibited vascular lesion formation and suppressed atrial natriuretic peptide (ANP) and transforming growth factor-beta1 (TGF-beta1), but this was not the case when using FR alone or hydralazine or benidipine plus FR.ConclusionsThese results suggest that benidipine may be useful for cardioprotective agents in preventing the cardiac dysfunction and remodeling associated with the BK-eNOS and oxidative stress pathway.American Journal of Hypertension (2008);21 2. 224-230. doi:10.1038/ajh.2007.51American Journal of Hypertension (2008);21 2. 224-230. doi:10.1038/ajh.2007.51.

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Publishing Authors By Initials

T Ohno,N Kobayashi,K Yoshida,H Fukushima,H Matsuoka,T Ohno,N Kobayashi,K Yoshida,H Fukushima,H Matsuoka,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of hypertension : journal of the

VOLUME: 21

Page Numbers: 224-30

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 10

MONTH: 01

YEAR: 2008

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803676

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts.

AFFILIATION: 1Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Hypertens

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts Related Publications

• A musculotendon contribution for multijoint hand control.
• Antibody against C-terminal Abeta selectively elevates plasma Abeta.
• Autocrine action of BMP2 regulates expression of GDNF-mRNA in sciatic Schwann cells.
• BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
• Benazepril slows progression of renal dysfunction in patients with non-diabetic renal disease.
• Bone morphogenetic protein-2 and retinoic acid induce neurotrophin-3 responsiveness in developing rat sympathetic neurons.
• CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.
• Combination Therapy With Telmisartan and Spironolactone Alleviates L-NAME Exacerbated Nephrosclerosis With an Increase in PPAR-gamma and Decrease in TGF-beta(1).
• Comparison of the Rear Impact Biofidelity of BioRID II and RID2.
• Comprehensive Analysis of Glucan Elicitor-Regulated Gene Expression in Tobacco BY-2 Cells Reveals a Novel MYB Transcription Factor Involved in the Regulation of Phenylpropanoid Metabolism.
• Continuation electroconvulsive therapy to prevent relapse of schizophrenia in relapse-prone patients.
• Defining regional variation in the material properties of human rib cortical bone and its effect on fracture prediction.
• Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration.
• Duodenal disruption diagnosed 5 days after blunt trauma in a 2-year-old child: report of a case.
• Effect of spatial position on visual search for 3-D objects.
• Implication of the HTLV-I bZIP factor gene in the leukemogenesis of adult T-cell leukemia.
• Lower birth weight is associated with higher resting heart rate during boyhood.
• Material properties of human rib cortical bone from dynamic tension coupon testing.
• Modeling effects of age and sex on cardiovascular variability responses to aerobic ergometer exercise.
• Molecular interactions of a soluble gibberellin receptor, GID1, with a rice DELLA protein, SLR1, and gibberellin.
• Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy.
• Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition.
• Purinergic P2X receptor activation induces emetic responses in ferrets and Suncus murinus (house musk shrews).
• Rapid count of microbial cells in dialysate.
• Regulation of glial cell line-derived neurotrophic factor responsiveness in developing rat sympathetic neurons by retinoic acid and bone morphogenetic protein-2.
• Site-Specific, Covalent Attachment of Poly(dT)-Modified Peptides To Solid Surfaces for Microarrays.
• Structural and material changes in the aging thorax and their role in crash protection for older occupants.
• Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.
• Visualization of yeast single-cells on fabric surface with a fluorescent glucose and their isolation for culture.
• [Behavioral changes and mental symptoms in patients with epilepsy: physiopathology, diagnosis, and therapy]