Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity.

Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Research Abstract Details 

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Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Abstract Text:

Liana V Basova,Igor V Kurnikov,Lei Wang,Vladimir B Ritov,Natalia A Belikova,Irina I Vlasova,Andy A Pacheco,Daniel E Winnica,Jim Peterson, Bayir,David H Waldeck,Valerian E Kagan,

Upon interaction with anionic phospholipids, particularly mitochondria-specific cardiolipin (CL), cytochrome c (cyt c) loses its tertiary structure and its peroxidase activity dramatically increases. CL-induced peroxidase activity of cyt c has been found to be important for selective CL oxidation in cells undergoing programmed death. During apoptosis, the peroxidase activity and the fraction of CL-bound cyt c markedly increase, suggesting that CL may act as a switch to regulate cyt c's mitochondrial functions. Using cyclic voltammetry and equilibrium redox titrations, we show that the redox potential of cyt c shifts negatively by 350-400 mV upon binding to CL-containing membranes. Consequently, functions of cyt c as an electron transporter and cyt c reduction by Complex III are strongly inhibited. Further, CL/cyt c complexes are not effective in scavenging superoxide anions and are not effectively reduced by ascorbate. Thus, both redox properties and functions of cyt c change upon interaction with CL in the mitochondrial membrane, diminishing cyt c's electron donor/acceptor role and stimulating its peroxidase activity.

Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Publishing Authors By Initials

LV Basova,IV Kurnikov,L Wang,VB Ritov,NA Belikova,II Vlasova,AA Pacheco,DE Winnica,J Peterson,H Bayir,DH Waldeck,VE Kagan,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemistry

VOLUME: 46

Page Numbers: 3423-34

Journal Abbreviation: Biochemistry

ISSN: 0006-2960

DAY: 24

MONTH: 02

YEAR: 2007

Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370623

Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Information

Substance Name: Electron Transport Complex IV

Registry Number: EC 1.9.3.1

Grant and Affiliation Information for Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity.

AFFILIATION: Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U19 AI 068021

ACRONYM: AI

MEDLINETA: Biochemistry

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