Cardiac sympathovagal modulation evaluated by short-term heart interval variability is subtly impaired in Alzheimer's disease.

Cardiac sympathovagal modulation evaluated by short-term heart interval variability is subtly impaired in Alzheimer's disease. Research Abstract Details 

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Cardiac sympathovagal modulation evaluated by short-term heart interval variability is subtly impaired in Alzheimer's disease. Abstract Text:

AIM: Alzheimer's disease affects several nervous structures involved with the autonomic nervous system. Therefore, the still scarce evaluation of the cardiac autonomic function in this disease is of great functional, clinical, prognostic and therapeutic relevance. METHODS: Time- and frequency-domain variability of 5-min R-R interval series in supine and standing positions was comparatively evaluated in 22 Alzheimer's disease subjects, aged 60-87 years (mean +/- standard error of the mean, 79.6 +/- 1.4) with variable cognitive impairment, and 24 healthy individuals, aged 60-91 years (68.6 +/- 1.6). The Student's t-test was used to compare the variability indices between the groups and logistic regression excluded the effects on these indices in the Alzheimer's group of confounding variables different from the control group (age, physical activity and caffeinated intake), at a significance level of P

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Cardiac sympathovagal modulation evaluated by short-term heart interval variability is subtly impaired in Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Geriatrics & gerontology international

VOLUME: 8

Page Numbers: 109-18

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ISSN: 1447-0594

DAY: 20

MONTH: Jun

YEAR: 2008

Cardiac sympathovagal modulation evaluated by short-term heart interval variability is subtly impaired in Alzheimer's disease. Information

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LANGUAGE: eng

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AFFILIATION: Clinical Medicine Area, Faculty of Medicine, University of Brasilia, and Geriatrics Medicine Center, Brasilia University Hospital, and Medical Sciences Postgraduate Course, Faculty of Medicine, University of Brasilia, Brasilia, Brazil.

Country: Japan

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MEDLINETA: Geriatr Gerontol Int

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