Cardiac KATP channels and ischemic preconditioning: current perspectives.

Cardiac KATP channels and ischemic preconditioning: current perspectives. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cardiac KATP channels and ischemic preconditioning: current perspectives. Abstract Text:

P E Light,

Ischemic preconditioning (IPC) is a naturally occurring protective mechanism in the heart and is triggered by brief ischemic insults preceding a sustained ischemic period. The artificial induction of the protective effects of IPC are potentially of great benefit to postinfarct patients and would serve to augment traditional surgical and thrombolytic treatment regimens. As yet, no agent has been developed to trigger IPC specifically. The mechanisms underlying IPC have been the focus of intense study, and many components of the IPC framework have been elucidated. Adenosine, noradrenalin, angiotensin II and endothelin are several of the key inducers of IPC. Signal transduction events downstream of receptor activation converging on protein kinase C stimulation are thought to trigger the intracellular pathways leading to 'preconditioning'. Although the complete sequence of events beneath IPC are not clear, several of the end effectors for the initiation of IPC are. For instance, activation of a class of potassium channels that are sensitive to internal ATP (KATP channels) can induce IPC and may be at least one of the targets for the action of protein kinase C. The precise mechanisms by which stimulation of KATP channels protects the myocardium are still under debate and are discussed in this review. It seems likely that both the plasma membrane and mitochondrial KATP channel populations are involved in IPC. Because KATP channels are rich and varied pharmacologically, it may be possible to target therapeutic agents at the cardiac channel isoform. Such compounds would likely meet the pharmacological criteria for a 'conditioning' agent.

Cardiac KATP channels and ischemic preconditioning: current perspectives. Publishing Authors By Initials

PE Light,

For similar chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents research abstracts see: chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents research

PUBMED ID PMID:

MEDLINE DATE:

Cardiac KATP channels and ischemic preconditioning: current perspectives. Journal Published:

PUBLICATION TYPE: Review

Journal: The Canadian journal of cardiology

VOLUME: 15

Page Numbers: 1123-30

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Oct

YEAR: 1999

Cardiac KATP channels and ischemic preconditioning: current perspectives. Information

Number of References: 79

LANGUAGE: eng

NlmUniqueID: 8510280

Cardiac KATP channels and ischemic preconditioning: current perspectives. Keywords Mesh Terms:

KEYWORDS: Neurotransmitter Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Cardiac KATP channels and ischemic preconditioning: current perspectives. Information

Substance Name: Adenosine Triphosphate

Registry Number: 56-65-5

Grant and Affiliation Information for Cardiac KATP channels and ischemic preconditioning: current perspectives.

AFFILIATION: University of Calgary, Calgary, Canada. plight@acs.ucalgary.ca

Country: CANADA

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Can J Cardiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cardiac KATP channels and ischemic preconditioning: current perspectives Related Publications

• "A child needs to be given a chance to succeed": Parents of individuals who use AAC describe the benefits and challenges of learning AAC technologies.
• A record for the recovery room.
• An experimental study of the effect of heparin on the local pathology of burns.
• Anesthesia for extremity amputations; a statistical review of 185 major amputation cases.
• Anion binding vs. sulfonamide deprotonation in functionalised ureas.
• Arterial stiffness and interdialytic weight gain influence ambulatory blood pressure patterns in hemodialysis patients.
• Cardiac KATP channels and ischemic preconditioning: current perspectives.
• Clinical manifestations of type IV ulna longitudinal dysplasia.
• Diagnostic utility of blood volume monitoring in hemodialysis patients.
• Effects of mild cardiovascular and cerebrovascular disorders on serial reaction time performance.
• Histological study of human scalps exhibiting various degrees of non-specific baldness.
• Influence of pain and depression on fear of falling, mobility, and balance in older male veterans.
• Interaction of some sterilizing filter materials with some technetium-99m radiopharmaceuticals.
• Intermittent 30s Intervals Performed at 100 and 70% VO2Peak Power (pVO2peak) Allow Trained Cyclists to Maintain VO2peak Longer than Continuous Intervals at 100% pVO2peak: 2417: Board #96 June 1 2:00 PM -3:30 PM.
• Kidney transplantation-second edition.
• Location not quantity of blood pressure measurements predicts mortality in hemodialysis patients.
• Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
• Lysozyme, a mediator of sepsis, impairs the cardiac neural adrenergic response by nonendothelial release of NO and inhibitory G protein signaling.
• Nuclear spin selection rules for reactive collision systems by the spin-modification probability method.
• Patterns of salivary cortisol secretion in pregnancy and implications for assessment protocols.
• Pleural fluid exchange in rabbits.
• Prevalence of pleural effusions post orthotopic heart transplantation.
• Reply to DiMasi, Hansen, and Grabowski.
• Slowing of response time in young and middle-aged hypertensive patients.
• Subwatt threshold cw Raman fiber-gas laser based on H2-filled hollow-core photonic crystal fiber.
• The Excite Trial: Relationship of intensity of constraint induced movement therapy to improvement in the wolf motor function test.
• Two-dimensional array transducers using thick film connection technology.
• Unilateral lymphocytic pleuritis as a manifestation of familial mediterranean Fever.
• Values and structure in the German health care systems.
• [Effect of anti-vascular endothelial growth factor antibody on pleurodesis induced by transforming growth factor-beta or doxycycline in rabbits]