Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up.

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Abstract Text:

Hui Zhou,Nico Schaefer,Martin Wolff,Hans-Peter Fischer,

A broad histomorphologic spectrum of ampullary carcinomas of Vater make a reproducible histologic classification difficult. Using cytokeratin immunohistochemistry, we present a new classification of ampullary carcinomas and analyze their clinical significance. Fifty-five invasive carcinomas of Vater's ampulla were histologically classified into pancreaticobiliary, intestinal, and other types. Serial sections of all carcinoma specimens were additionally stained with antibodies to cytokeratins (CK7, CK20), apomucins (MUC1, MUC2, MUC5AC), CEA, CA19-9, Ki67, and p53. Follow-up of patients from 4 months to 22 years after surgery (mean interval, 51.6 months) was evaluated. Most carcinomas of the ampulla of Vater were of immunohistochemically pancreaticobiliary type (iPT, CK7+, CK20-; 54.5%) or intestinal type (immunohistochemically intestinal type [iIT], CK7-, CK20+; 23.6%). Some carcinomas of immunohistochemically "other" type (iOT both CK7+ and CK20+ or CK7- and CK20-; 21.8%) had precursor lesions of iIT or iPT. Carcinomas positive for MUC2 or CEA were associated with iIT (MUC2, P < 0.001; CEA, P = 0.003), whereas MUC5AC-positive carcinomas were related to iPT (P = 0.005). Our classification based on cytokeratin-immunohistochemistry correlated well with the histologic classification according to published criteria (kappa-coefficient = 0.398; P < 0.001). Furthermore, histologically unusual types could be histogenetically related to pancreaticobiliary duct mucosa or intestinal mucosa. Therefore, all 4 signet-ring cell carcinomas were iIT carcinomas. Thus, cytokeratin immunohistochemistry allows a reproducible, histogenetically based categorization of ampullary carcinomas. However, neither histopathologic nor immunohistochemical subgroups significantly correlated with clinical outcome in our German collective. The overall survival was significantly shorter in males (P = 0.032) and patients with positive nodal stage (N1 < N0; P = 0.0025).

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Publishing Authors By Initials

H Zhou,N Schaefer,M Wolff,HP Fischer,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

PUBMED ID PMID:

MEDLINE DATE:

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of surgical pathology

VOLUME: 28

Page Numbers: 875-82

Journal Abbreviation: Am. J. Surg. Pathol.

ISSN: 0147-5185

DAY: 30

MONTH: Jul

YEAR: 2004

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707904

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: analysis

Chemical & Substance for Abstract: Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up. Information

Substance Name: Keratins

Registry Number: 68238-35-7

Grant and Affiliation Information for Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up.

AFFILIATION: Department of Pathology, University of Bonn, Bonn, Germany. zhou@ukb.uni-bonn.de

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Surg Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up Related Publications

• A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway.
• A prospective masked observational study of uterine contraction frequency in twins.
• A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis.
• Blastocystis hominis and travelers.
• Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up.
• Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins.
• Composition of the Volatile Oils from the Roots, Leaves and Fruits of Different Taxa of Apium graveolens.
• Cyanogenesis in Passiflora spp.
• Detection of Brugia parasite DNA in human blood by real-time PCR.
• Detection of scale-specific community dynamics using wavelets.
• Do age- and sex-related variations reliably reflect body size in non-human primate vocalizations? A review.
• Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats.
• Effect of oxygen concentration in the incubator's gas phase on the development of cultured preimplantation rabbit embryos.
• Expression of Nox1 in 3T3 cells increases cellular acid production but not proton conductance.
• Identification of genes that interact with Drosophila liquid facets.
• Maternal fish consumption, mercury levels, and risk of preterm delivery.
• Nitrogen sparing effects and mechanisms of branched-chain amino acids in the injured rat.
• Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry.
• Regulation of seed size by hypomethylation of maternal and paternal genomes.
• Role of myokines in exercise and metabolism.
• Spinal cord ependymomas.
• The Essential Oil in Lamina and Petiole of Heracleum dissectum Leaves.
• The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein.
• The determination of (R)- and (S)-glutethimide and the corresponding 4-hydroxyglutethimide metabolises in human serum and urine using a Pirkle-type HPLC chiral stationary phase.
• The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis.
• The use of branched chain amino acids (BCAA) in acute hepatic encephalopathy.
• Translocation mechanism of long sugar chains across the maltoporin membrane channel.
• Travel medicine: an American view of the Australian perspective.
• Use of buprenorphine in pregnancy: patient management and effects on the neonate.
• [Knowledge and practices by adolescents in preventing occupational injuries: a qualitative study]