Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum.

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Abstract Text:

Michiru Hirasawa,Xinjie Xu,Robert B Trask,Terry P Maddatu,Britt A Johnson, Naggert,Patsy M Nishina,Akihiro Ikeda,

Carbonic anhydrase related protein 8 (Car8) is known to be abundantly expressed in Purkinje cells (PCs), and its genetic mutation causes a motor coordination defect. To determine the underlying mechanism, we analyzed the mouse cerebellum carrying a Car8 mutation. Electrophysiological analysis showed that spontaneous excitatory transmission was largely diminished while paired pulse ratio at parallel fiber-PC synapses was comparable to wild-type, suggesting functional synapses have normal release probability but the number of functional synapses may be lower in mutants. Light microscopic study revealed an abnormal extension of climbing fibers to the distal PC dendrites. At the ultrastructural level, we found numerous PC spines not forming synapses primarily in distal dendrites and occasionally multiple spines contacting a single varicosity. These abnormalities of parallel fiber-PC synapses may underlie the functional defect in excitatory transmission. Thus, Car8 plays a critical role in synaptogenesis and/or maintenance of proper synaptic morphology and function in the cerebellum.

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Publishing Authors By Initials

M Hirasawa,X Xu,RB Trask,TP Maddatu,BA Johnson,JK Naggert,PM Nishina,A Ikeda,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

PUBMED ID PMID:

MEDLINE DATE:

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and cellular neurosciences

VOLUME: 35

Page Numbers: 161-70

Journal Abbreviation:

ISSN: 1044-7431

DAY: 23

MONTH: 02

YEAR: 2007

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100095

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: physiology

Chemical & Substance for Abstract: Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum.

AFFILIATION: Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6. michiru@mun.ca

Country: United States

AGENCY: United States NIGMS

GRANT: 5 T32 GM07133

ACRONYM: GM

MEDLINETA: Mol Cell Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum Related Publications

• A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis.
• Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.
• Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.
• Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3.
• Carbonic anhydrase related protein 8 mutation results in aberrant synaptic morphology and excitatory synaptic function in the cerebellum.
• Compact superconducting ring at ritsumeikan university.
• Comparative evaluation of biomarkers of occupational exposure to toluene.
• Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats.
• Different effects of vitamin E on the growth and morphological differentiation of 4 murine neuroblastoma cell lines in vitro.
• Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis.
• Dyke-Davidoff-Masson syndrome manifested by seizure in late childhood: a case report.
• Early gene expression analyzed by cDNA microarray and RT-PCR in osteoblasts cultured with water-soluble and low molecular chitooligosaccharide.
• Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice.
• En bloc resection of the temporal bone by the lateral approach in carcinoma of the middle ear associated with skull base infiltration with reference to the resection of the petrous apex.
• Erythropoietin attenuates the development of experimental autoimmune myocarditis.
• Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice.
• Inhomogeneity of local temperature in small clusters in microcanonical equilibrium.
• Interactivating feedback loops within the mammalian clock: BMAL1 is negatively autoregulated and upregulated by CRY1, CRY2, and PER2.
• Lineage-specific expression of granulocyte colony-stimulating factor and thrombopoietin receptors in terminally differentiated hematopoietic cells.
• Mainstream breast cancer radiology perspective.
• Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier.
• Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test.
• Possible involvement of bone morphogenetic protein 2 in heterotopic ossification in metastatic lesion from urothelial carcinoma of bladder.
• Promising techniques for breast cancer detection, diagnosis, and staging using non-ionizing radiation imaging techniques.
• Reduced synaptic vesicle density and aberrant synaptic localization caused by a splice site mutation in the Rs1h gene.
• Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population.
• Slow absorption of conjugated linoleic acid in rat intestines, and similar absorption rates of 9c,11t-conjugated linoleic acid and 10t,12c-conjugated linoleic acid.
• Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
• Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.
• mPer2 antisense oligonucleotides inhibit mPER2 expression but not circadian rhythms of physiological activity in cultured suprachiasmatic nucleus neurons.