Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.

Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Research Abstract Details 

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Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Abstract Text:

Stephen J Freedland,John Mavropoulos,Amy Wang,Medha Darshan,Wendy Demark-Wahnefried,William J Aronson,Pinchas Cohen,David Hwang,Bercedis Peterson,Timothy Fields,Salvatore V Pizzo,William B Isaacs,Stephen J Freedland,John Mavropoulos,Amy Wang,Medha Darshan,Wendy Demark-Wahnefried,William J Aronson,Pinchas Cohen,David Hwang,Bercedis Peterson,Timothy Fields,Salvatore V Pizzo,William B Isaacs,Stephen J Freedland,John Mavropoulos,Amy Wang,Medha Darshan,Wendy Demark-Wahnefried,William J Aronson,Pinchas Cohen,David Hwang,Bercedis Peterson,Timothy Fields,Salvatore V Pizzo,William B Isaacs,

BACKGROUND: Recent evidence suggests carbohydrate intake may influence prostate cancer biology. We tested whether a no-carbohydrate ketogenic diet (NCKD) would delay prostate cancer growth relative to Western and low-fat diets in a xenograft model. METHODS: Seventy-five male SCID mice were fed a NCKD (84% fat-0% carbohydrate-16% protein kcal), low-fat (12% fat-72% carbohydrate-16% protein kcal), or Western diet (40% fat-44% carbohydrate-16% protein kcal). Low-fat mice were fed ad libitum and the other arms fed via a modified-paired feeding protocol. After 24 days, all mice were injected with LAPC-4 cells and sacrificed when tumors approached 1,000 mm(3). RESULTS: Despite consuming equal calories, NCKD-fed mice lost weight (up to 15% body weight) relative to low-fat and Western diet-fed mice and required additional kcal to equalize body weight. Fifty-one days after injection, NCKD mice tumor volumes were 33% smaller than Western mice (rank-sum, P = 0.009). There were no differences in tumor volume between low-fat and NCKD mice. Dietary treatment was significantly associated with survival (log-rank, P = 0.006), with the longest survival among the NCKD mice, followed by the low-fat mice. Serum IGFBP-3 was highest and IGF-1:IGFBP-3 ratio was lowest among NCKD mice while serum insulin and IGF-1 levels were highest in Western mice. NCKD mice had significantly decreased hepatic fatty infiltration relative to the other arms. CONCLUSIONS: In this xenograft model, despite consuming more calories, NCKD-fed mice had significantly reduced tumor growth and prolonged survival relative to Western mice and was associated with favorable changes in serum insulin and IGF axis hormones relative to low-fat or Western diet.

Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Publishing Authors By Initials

SJ Freedland,J Mavropoulos,A Wang,M Darshan,W Demark-Wahnefried,WJ Aronson,P Cohen,D Hwang,B Peterson,T Fields,SV Pizzo,WB Isaacs,SJ Freedland,J Mavropoulos,A Wang,M Darshan,W Demark-Wahnefried,WJ Aronson,P Cohen,D Hwang,B Peterson,T Fields,SV Pizzo,WB Isaacs,SJ Freedland,J Mavropoulos,A Wang,M Darshan,W Demark-Wahnefried,WJ Aronson,P Cohen,D Hwang,B Peterson,T Fields,SV Pizzo,WB Isaacs,

For similar xenograft model antitumor assays research abstracts see: xenograft model antitumor assays research

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Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Prostate

VOLUME: 68

Page Numbers: 11-9

Journal Abbreviation: Prostate

ISSN: 0270-4137

DAY: 1

MONTH: Jan

YEAR: 2008

Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8101368

Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Keywords Mesh Terms:

KEYWORDS: Xenograft Model Antitumor Assays

MESH TERMS: pathology

Chemical & Substance for Abstract: Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Information

Substance Name: Insulin-Like Growth Factor I

Registry Number: 67763-96-6

Grant and Affiliation Information for Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.

AFFILIATION: Department of Surgery, Durham VA Medical Center, Durham, North Carolina 27710, USA. steve.freedland@duke.edu

Country: United States

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MEDLINETA: Prostate

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