Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice.

Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Research Abstract Details 

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Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Abstract Text:

Piotr J Wysocki,Eliza P Kwiatkowska,Urszula Kazimierczak,Wiktoria Suchorska,Dariusz W Kowalczyk,Andrzej Mackiewicz,

PURPOSE: Antitumor potential of angiotensin-converting enzyme inhibitors has been shown in different preclinical settings, which always involved immunocompromised organisms or nonimmunogenic tumor models. In our study, we wanted to evaluate the effect of captopril on growth of immunogenic tumors in immunocompetent animals. EXPERIMENTAL DESIGN: We used different murine tumor models to evaluate the effect of captopril on tumor take and survival of tumor-bearing immunocompetent and immunocompromised mice. We used an orthotopic renal cell cancer model and highly immunogenic tumor model, which were based on kidney subcapsular injection of RenCa cells or s.c. injection of MethA cells, respectively. To show the influence of captopril on antigen-specific immune responses, we have used two model antigens (green fluorescent protein and beta-galactosidase). RESULTS: Captopril decreased survival of RenCa-bearing, immunocompetent mice in a dose-dependent manner and in adjuvant setting. In nephrectomized mice, captopril shortened their survival. Captopril promoted formation of immunogenic MethA sarcoma tumors but had no effect on nonimmunogenic melanoma cells (B78-H1). Treatment of immunocompromised mice bearing MethA tumors or RenCa kidney tumors with captopril did not affect tumor formation nor survival, respectively. Captopril-treated mice immunized with AdLacZ or AdGFP vectors did not generate or generated decreased numbers of antigen-specific CD8+ T cells, respectively. However, they showed B-cell responses represented by infiltration of MethA tumors with activated B cells and dramatically increased serum level of beta-galactosidase-specific antibodies. CONCLUSIONS: Our results show a novel role of captopril in tumor biology and the tumor-promoting properties of captopril seem to be associated with its immunomodulatory potential.

Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Publishing Authors By Initials

PJ Wysocki,EP Kwiatkowska,U Kazimierczak,W Suchorska,DW Kowalczyk,A Mackiewicz,

For similar xenograft model antitumor assays research abstracts see: xenograft model antitumor assays research

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Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical cancer research : an official journal of

VOLUME: 12

Page Numbers: 4095-102

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Jul

YEAR: 2006

Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Information

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LANGUAGE: eng

NlmUniqueID: 9502500

Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Keywords Mesh Terms:

KEYWORDS: Xenograft Model Antitumor Assays

MESH TERMS: pathology

Chemical & Substance for Abstract: Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice. Information

Substance Name: Captopril

Registry Number: 62571-86-2

Grant and Affiliation Information for Captopril, an angiotensin-converting enzyme inhibitor, promotes growth of immunogenic tumors in mice.

AFFILIATION: Department of Cancer Immunology, University of Medical Sciences at GreatPoland Cancer Center, Poznan, Poland. pwysocki@plusnet.pl

Country: United States

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MEDLINETA: Clin Cancer Res

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