Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats.

Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Research Abstract Details 

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Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Abstract Text:

Larry L Bellinger,Robert Spears,Christopher M King,Fred Dahm,Bob Hutchins,Carolyn A Kerins,Phillip R Kramer,

Computerized meal pattern analysis, and more specifically meal duration, has recently been used as a non-invasive biological marker of nociception in the temporomandibular joint (TMJ). Cells responsible for the nociceptive response in the inflamed TMJ may include capsaicin (CAP) sensitive neurons. To test the role of CAP sensitive neurons in acute nociceptive responses first, male and female rats were treated neonatally with vehicle or CAP, an agent known to destroy a majority of C fibers. Second, after 56 days the rats were divided into four groups: neonatal vehicle-injected and treated with and without complete Freund's adjuvant (CFA). Treatment groups included neonatal non-CAP vehicle treated and TMJ not-injected (CON); vehicle treated and TMJ CFA injected (CFA); CAP-treated and not-injected (CAP); and CAP-treated and CFA injected (CAP+CFA). Meal patterns were analyzed for two days after injection. CFA-injection in non-CAP-treated rats lengthened meal duration on the first and second day after treatment in the males, but only on the first day in the females. CAP treatment in male and female rats prevented significant lengthening of meal duration induced by CFA. CAP treatment attenuated the CFA-induced increase in calcitonin gene-related peptide expression in the trigeminal ganglia similarly in males and females. The data suggests CAP-sensitive neurons are responsible, in part, for transmission of acute nociceptive responses associated with CFA administration and suggest gender can affect nociception in the inflamed TMJ region.

Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Publishing Authors By Initials

LL Bellinger,R Spears,CM King,F Dahm,B Hutchins,CA Kerins,PR Kramer,

For similar musculoskeletal diseases: jaw diseases: mandibular diseases: craniomandibular disorders: temporomandibular joint disorders research abstracts see: musculoskeletal diseases: jaw diseases: mandibular diseases: craniomandibular disorders: temporomandibular joint disorders research

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Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Physiology & behavior

VOLUME: 90

Page Numbers: 782-9

Journal Abbreviation: Physiol. Behav.

ISSN: 0031-9384

DAY: 18

MONTH: 01

YEAR: 2007

Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 151504

Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Keywords Mesh Terms:

KEYWORDS: Temporomandibular Joint Disorders

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats. Information

Substance Name: TRPV Cation Channels

Registry Number: 0

Grant and Affiliation Information for Capsaicin sensitive neurons role in the inflamed TMJ acute nociceptive response of female and male rats.

AFFILIATION: Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, Texas 75246, United States. lbellinger@bcd.tamhsc.edu

Country: United States

AGENCY: United States NIDCR

GRANT: T35 DE07188

ACRONYM: DE

MEDLINETA: Physiol Behav

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