Capecitabine: the new generation of fluoropyrimidines in colorectal cancer.

Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. Research Abstract Details 

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Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. Abstract Text:

Syma Iqbal,Heinz-Josef Lenz,

Colorectal cancer is the second leading cause of cancer death in the USA and fluoropyrimidines have been the mainstay of treatment for over 40 years. Currently, capecitabine is the only orally available fluoropyrimidine approved for treatment in the USA. As a single agent it has demonstrated activity and equivalence to 5-fluorouracil (5-FU) intravenous administration via the Mayo Clinic regimen, in both the metastatic and adjuvant settings. Ongoing clinical trials are evaluating the efficacy of capecitabine in combination with oxaliplatin and irinotecan as more convenient substitutes for infusional 5-FU in the 5-FU/leucovorin/oxaliplatin and 5-FU/irinotecan regimens.

Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. Publishing Authors By Initials

S Iqbal,HJ Lenz,

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Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of anticancer therapy

VOLUME: 4

Page Numbers: 947-55

Journal Abbreviation: Expert Rev Anticancer Ther

ISSN: 1744-8328

DAY: 5

MONTH: Dec

YEAR: 2004

Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. Information

Number of References: 42

LANGUAGE: eng

NlmUniqueID: 101123358

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Grant and Affiliation Information for Capecitabine: the new generation of fluoropyrimidines in colorectal cancer.

AFFILIATION: University of Southern California, Kenneth Norris Comprehensive Cancer Center, Division of Medical Oncology, 1441 Eastlake Avenue, Suite 3457, Los Angeles, CA 90033, USA. iqbal_s@ccnt.hsc.usc.edu

Country: England

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MEDLINETA: Expert Rev Anticancer Ther

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