Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies.

Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. Research Abstract Details 

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Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. Abstract Text:

Catherine L Clark,Klaudia Kosowska-Shick,Lois M Ednie,Peter C Appelbaum,Catherine L Clark,Klaudia Kosowska-Shick,Lois M Ednie,Peter C Appelbaum,

Testing of 12 pneumococcal strains with differing resistotypes [including tet(M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all beta-lactams, macrolides/ketolides, and quinolones tested.

Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. Publishing Authors By Initials

CL Clark,K Kosowska-Shick,LM Ednie,PC Appelbaum,CL Clark,K Kosowska-Shick,LM Ednie,PC Appelbaum,

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Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 4196-201

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 17

MONTH: 09

YEAR: 2007

Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA. pappelbaum@psu.edu.

Country: United States

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MEDLINETA: Antimicrob Agents Chemother

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