Cannabinoid receptors and the regulation of bone mass.

Cannabinoid receptors and the regulation of bone mass. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cannabinoid receptors and the regulation of bone mass. Abstract Text:

I Bab,A Zimmer,I Bab,A Zimmer,I Bab,A Zimmer,

A functional endocannabinoid system is present in several mammalian organs and tissues. Recently, endocannabinoids and their receptors have been reported in the skeleton. Osteoblasts, the bone forming cells, and osteoclasts, the bone resorbing cells, produce the endocannabinoids anandamide and 2-arachidonoylglycerol and express CB2 cannabinoid receptors. Although CB2 has been implicated in pathological processes in the central nervous system and peripheral tissues, the skeleton appears as the main system physiologically regulated by CB2. CB2-deficient mice show a markedly accelerated age-related bone loss and the CNR2 gene (encoding CB2) in women is associated with low bone mineral density. The activation of CB2 attenuates ovariectomy-induced bone loss in mice by restraining bone resorption and enhancing bone formation. Hence synthetic CB2 ligands, which are stable and orally available, provide a basis for developing novel anti-osteoporotic therapies. Activation of CB1 in sympathetic nerve terminals in bone inhibits norepinephrine release, thus balancing the tonic sympathetic restrain of bone formation. Low levels of CB1 were also reported in osteoclasts. CB1-null mice display a skeletal phenotype that is dependent on the mouse strain, gender and specific mutation of the CB1 encoding gene, CNR1.British Journal of Pharmacology (2008) 153, 182-188; doi:10.1038/sj.bjp.0707593; published online 10 December 2007.

Cannabinoid receptors and the regulation of bone mass. Publishing Authors By Initials

I Bab,A Zimmer,I Bab,A Zimmer,I Bab,A Zimmer,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cannabinoid receptors and the regulation of bone mass. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of pharmacology

VOLUME: 153

Page Numbers: 182-8

Journal Abbreviation: Br. J. Pharmacol.

ISSN: 0007-1188

DAY: 10

MONTH: 12

YEAR: 2007

Cannabinoid receptors and the regulation of bone mass. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7502536

Cannabinoid receptors and the regulation of bone mass. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cannabinoid receptors and the regulation of bone mass. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cannabinoid receptors and the regulation of bone mass.

AFFILIATION: 1Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem, Israel.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cannabinoid receptors and the regulation of bone mass Related Publications

• Alternative splicing and protein structure evolution.
• AutoPSI: a database for automatic structural classification of protein sequences and structures.
• Cannabinoid receptors and the regulation of bone mass.
• Chemosensory reception, behavioral expression, and ecological interactions at multiple trophic levels.
• Clinical trials and medical care: defining the therapeutic misconception.
• Education, gender, and functional transitions among Indonesian elderly.
• Environmental modulation of anxiety-related neuronal activity and behaviors.
• Event-related potential repetition effects at encoding predict memory performance at test.
• FZD3 is not a risk gene for schizophrenia: a case-control study in a Caucasian sample.
• Functional genomics, evo-devo and systems biology: a chance to overcome complexity?
• GLYCERIN SOLUTION AS A PRESERVATIVE FOR SPECIMENS OF FECES FOR BACTERIOLOGICAL EXAMINATION.
• Heinz body formation by certain chemical agents.
• Infectious diseases. Isolated tribe gives clues to the origins of syphilis.
• Microbiota of exposed root surfaces after fluoride, chlorhexidine, and periodontal maintenance therapy: a 3-year evaluation.
• Neuroprotective effects of the AMPA antagonist PNQX in oxygen-glucose deprivation in mouse hippocampal slice cultures and global cerebral ischemia in gerbils.
• Poverty, wealth inequality and health among older adults in rural Cambodia.
• Preproenkephalin knockout mice show no depression-related phenotype.
• ProSAS: a database for analyzing alternative splicing in the context of protein structures.
• Sex and flow: the consequences of fluid shear for sperm egg interactions.
• Synergistic mutations produce blue-shifted bioluminescence in firefly luciferase.
• Synthesis and biological evaluation in rat and cat of [(18)F]12ST05 as a potential 5-HT(6) PET radioligand.
• Tension gangrene of the cecum due to cancer of the sigmoid.
• The dentate mossy fibers: structural organization, development and plasticity.
• The scent of danger: arginine as an olfactory cue of reduced predation risk.
• Time course of hypoxia-induced lung injury in rats.
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]