Canine Dal blood type: A red cell antigen lacking in some Dalmatians.

Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Research Abstract Details 

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Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Abstract Text:

Marie-Claude Blais,Lisa Berman,Donna A Oakley,Urs Giger,

BACKGROUND: Based upon alloantibodies produced after sensitizing dogs with transfused blood, more than a dozen blood group systems have been recognized thus far, and some have been classified as dog erythrocyte antigens (DEA). HYPOTHESIS: A new canine red cell antigen was suspected, based on the development of specific alloantibodies in a Dalmatian previously sensitized by blood transfusions. ANIMALS: Twenty-six Dalmatians (including 1 Dalmatian in need of blood compatibility studies); 55 canine blood donors. METHODS: Serologic tests, including blood typing, crossmatching, and direct Coombs' test were performed by standard tube techniques and a novel gel column technology adapted from human blood banking. RESULTS: By day 40 after transfusion of an anemic Dalmatian, all major crossmatch tests to 55 non-Dalmatian dogs were incompatible. The 2 initial donors, who were compatible before transfusion, were also now incompatible, suggesting the development of an alloantibody to a common red cell antigen. No siblings were available, but 4 of 25 unrelated Dalmatians were crossmatch compatible, suggesting that they were missing the same red cell antigen. The patient was blood typed DEA 1.1, 3, 4, and 5 positive, but DEA 7 negative. Further blood typing and crossmatching results did not support an association to any of these known blood types. The alloantibodies produced were determined to be of the immunoglobulin G class. CONCLUSIONS AND CLINICAL IMPORTANCE: Based upon the identification of an acquired alloantibody in a Dalmatian, a presumably new common blood type named Dal was identified. Dalmatians lacking the Dal antigen are likely at risk of delayed and acute hemolytic transfusion reactions.

Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Publishing Authors By Initials

MC Blais,L Berman,DA Oakley,U Giger,

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MEDLINE DATE:

Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of veterinary internal medicine / American

VOLUME: 21

Page Numbers: 281-6

Journal Abbreviation:

ISSN: 0891-6640

DAY: 3

MONTH: 12

YEAR: 2007

Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8708660

Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Keywords Mesh Terms:

KEYWORDS: Male

MESH TERMS: blood

Chemical & Substance for Abstract: Canine Dal blood type: A red cell antigen lacking in some Dalmatians. Information

Substance Name: Isoantibodies

Registry Number: 0

Grant and Affiliation Information for Canine Dal blood type: A red cell antigen lacking in some Dalmatians.

AFFILIATION: Section of Medical Genetics and Penn Animal Blood Bank, School of Veterinary Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA 19104-6010, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR02512

ACRONYM: RR

MEDLINETA: J Vet Intern Med

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