Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population.

Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Research Abstract Details 

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Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Abstract Text:

Lene Christiansen,Qihua Tan,Maria Iachina,Lise Bathum,Torben A Kruse,Matthew McGue,Kaare Christensen,

BACKGROUND: Depressed mood is a major concern in the elderly, with consequences for morbidity and mortality. Previous studies have demonstrated that genetic factors in depression and subsyndromal depressive symptoms are no less important in the elderly than during other life stages. Variations in genes included in the serotonin system have been suggested as risk factors for various psychiatric disorders but may also serve as candidates for normal variations in mood. METHODS: This study included 684 elderly Danish twins to investigate the influence of 11 polymorphisms in 7 serotonin system genes on the mean level of depression symptomatology assessed over several years, reflecting individuals' underlying mood level. RESULTS: A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. We also found that a specific haplotype in VMAT2, the gene encoding the vesicular monoamine transporter, was significantly associated with depression symptoms in men (p= .007). CONCLUSIONS: These results suggest that variations in genes encoding the components of serotonin metabolism may influence the basic mood level and that different genetic factors may apply in men and women.

Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Publishing Authors By Initials

L Christiansen,Q Tan,M Iachina,L Bathum,TA Kruse,M McGue,K Christensen,

For similar proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: vesicular neurotransmitter transport proteins: vesicular biogenic amine transport proteins: vesicular monoamine transport proteins research abstracts see: proteins: carrier proteins: membrane transport proteins: ion pumps: antiporters: vesicular neurotransmitter transport proteins: vesicular biogenic amine transport proteins: vesicular monoamine transport proteins research

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Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Journal Published:

PUBLICATION TYPE: Twin Study

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 223-30

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 27

MONTH: 06

YEAR: 2006

Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Keywords Mesh Terms:

KEYWORDS: Vesicular Monoamine Transport Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Information

Substance Name: tyrosine phosphate hydrolase

Registry Number: EC 3.1.3.-

Grant and Affiliation Information for Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population.

AFFILIATION: Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark. lchristiansen@health.sdu.dk

Country: United States

AGENCY: United States NIA

GRANT: NIA-P01-AG08761

ACRONYM: AG

MEDLINETA: Biol Psychiatry

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