Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension.

Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension. Research Abstract Details 

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Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension. Abstract Text:

Hiroyoshi Ono,Shinya Minatoguchi,Kazuhiro Watanabe,Yoshihisa Yamada,Takahisa Mizukusa,Hironobu Kawasaki,Hidemi Takahashi,Takashi Uno,Tatsuo Tsukamoto,Kunihiko Hiei,Hisayoshi Fujiwara,

Candesartan has been reported to produce nitric oxide (NO) and to decrease oxidative stress in animal studies. We investigated candesartan's effect on the production of NO and oxidative stress as well as on carotid intima-media thickness (IMT) in hypertensive patients. One-hundred age-matched hypertensive patients were enrolled into an angiotensin II receptor blocker (ARB) group (n=50) or a non-ARB group (n=50). The ARB group was treated with candesartan 8 mg and, when needed, Ca channel blockers, angiotesin-converting enzyme (ACE) inhibitors, and/or beta-blockers. The non-ARB group was treated with drugs other than ARB. Carotid IMT was assessed by echocardiography before and 12 and 24 months after treatment. The urine levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and the serum levels of NOx, an indicator of NO, were measured. Blood pressure decreased to below 140/90 mmHg to the same extent in both groups. Carotid IMT decreased significantly in the ARB group, but not in the non-ARB group, at 12 and 24 months after treatment. The urine levels of 8-OHdG decreased significantly at 6 and 12 months after treatment in the ARB group but did not decrease in the non-ARB group. The serum levels of NOx increased significantly at 6 and 12 months after treatment in the ARB group but not in the non-ARB group. In conclusion, candesartan decreases carotid IMT by enhancing NO production and decreasing oxidative stress in patients with hypertension. (Hypertens Res 2008; 31: 271-279).

Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension. Publishing Authors By Initials

H Ono,S Minatoguchi,K Watanabe,Y Yamada,T Mizukusa,H Kawasaki,H Takahashi,T Uno,T Tsukamoto,K Hiei,H Fujiwara,

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Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hypertension research : official journal of the Ja

VOLUME: 31

Page Numbers: 271-9

Journal Abbreviation: Hypertens. Res.

ISSN: 0916-9636

DAY: 24

MONTH: Feb

YEAR: 2008

Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension. Information

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LANGUAGE: eng

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AFFILIATION: Ibi Kosei Hospital.

Country: Japan

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MEDLINETA: Hypertens Res

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