CAMPATH-1 antibodies in stem-cell transplantation.

CAMPATH-1 antibodies in stem-cell transplantation. Research Abstract Details 

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CAMPATH-1 antibodies in stem-cell transplantation. Abstract Text:

BACKGROUND: CAMPATH-1 (CD52) Abs have been used in stem-cell transplants for the prevention of GvHD and graft rejection. These complications can effectively be prevented by depletion of T lymphocytes from both donor and recipient. However, donor lymphocytes might contribute an anti-leukemia effect and lymphocyte depletion may exacerbate problems with immune reconstitution. There is a fine balance between the risks of GvHD and host-versus-graft reactions, relapse and infection. METHODS: Clinical outcomes for 4264 patients were reported to a central registry and analyzed by univariate and multivariate methods to determine the superior protocols. Various protocols of lymphocyte depletion were tested, using either CAMPATH-1M (IgM) plus complement or CAMPATH-1G (IgG2b) to treat the donor BM ex vivo and CAMPATH-1G in vivo to treat the recipient. The humanized antibody CAMPATH-1H has recently replaced CAMPATH-1G. A meeting of the clinical collaborators was convened to discuss the results and to review the experiences of individual centers. RESULTS: Interest focused on the use of mobilized PBSC for transplantation and on the use of reduced-intensity conditioning regimens ('mini' or 'non-Correspondence myeloablative' transplants). These approaches are likely to become increasingly important in the future and will allow transplant procedures to be used for relatively older patients. The use of CAMPATH-1G or CAMPATH-1H was associated with a low incidence of GvHD or rejection, though there were some differences that might be related to the longer half-life of the humanized antibody. An unexpected and apparently paradoxical effect of post-transplant CYA was observed - it appeared to reduce the risk of dying from infection after 6 months. Although part of the benefit could be explained by a reduction in GvHD, the effect was still evident when patients with GvHD or graft rejection were excluded from analysis. DISCUSSION: CAMPATH-1H appears to have a useful role in the prevention of graft rejection and GvHD, particularly in patients who are at high risk of these complications. It can equally well be used by admixture with the infused stem cells, or by administration to the patient prior to the transplant. Future studies will seek to understand the mechanism of the CYA effect and to improve the quality of immune reconstitution.

CAMPATH-1 antibodies in stem-cell transplantation. Publishing Authors By Initials

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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CAMPATH-1 antibodies in stem-cell transplantation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cytotherapy

VOLUME: 3

Page Numbers: 145-64

Journal Abbreviation: Cytotherapy

ISSN: 1465-3249

DAY: 24

MONTH: 04

YEAR: 2001

CAMPATH-1 antibodies in stem-cell transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 100895309

CAMPATH-1 antibodies in stem-cell transplantation. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: immunology

Chemical & Substance for Abstract: CAMPATH-1 antibodies in stem-cell transplantation. Information

Substance Name: alemtuzumab

Registry Number: 0

Grant and Affiliation Information for CAMPATH-1 antibodies in stem-cell transplantation.

AFFILIATION: Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Country: England

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MEDLINETA: Cytotherapy

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