Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins.

Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Research Abstract Details 

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Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Abstract Text:

Shvetambri Arora,Parag Vohra,Ajit Kumar,Yogesh Kumar Tyagi,Hanumantharao Guru Raj,Bilekere Srinivasarao Dawarkanath,Daman Saluja,Luciano Saso,Virinder Singh Parmar,

The Transacetylase function of Calreticulin (CR) catalyzing the transfer of acetyl groups from acetoxycoumarins (AC) to certain proteins was identified for the first time in our laboratory. Protein acetyltransferase action of CR was termed Calreticulin Transacetylase (CRTAase). In the present work, CRTAase of rat tracheal smooth muscle cells (TSMC) was characterized with respect to the specificity for various AC and its role in the activation of nitric oxide synthase (NOS). 7,8-Diacetoxy-4-methylcoumarin (DAMC), a model AC, when incubated with TSMC along with L-arginine caused profound activation of NOS as compared to that with L-arginine alone. Further, the inclusion of N-omega-nitro-L-arginine methyl ester (L-NAME) along with DAMC resulted in the reduction of NO levels of TSMC to that of control, there by confirming the activation of TSMC NOS. Also, several AC were found to activate TSMC NOS in tune with their specificities to CRTAase. The results presented in this paper bear evidence for the activation of TSMC NOS by AC and their effectiveness to enhance NO of airway cells may be expected to find useful applications in respiratory diseases.

Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Publishing Authors By Initials

S Arora,P Vohra,A Kumar,YK Tyagi,HG Raj,BS Dawarkanath,D Saluja,L Saso,VS Parmar,

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Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 31

Page Numbers: 709-13

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 1

MONTH: Apr

YEAR: 2008

Calreticulin transacetylase catalyzed activation of rat tracheal smooth muscle cell nitric oxide synthase by acetoxycoumarins. Information

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LANGUAGE: eng

NlmUniqueID: 9311984

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AFFILIATION: Department of Biochemistry, V. P. Chest Institute, University of Delhi.

Country: Japan

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MEDLINETA: Biol Pharm Bull

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