[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Abstract Text:

Wei-min Li,Hong-jie Xue,Yue Li,Li Zhang,Yong-tai Gong,Li Sheng,Shan Chu,

OBJECTIVE: To study the relation of the structural remodeling processes and activation of calpain I. METHODS: Fifteen dogs were randomly divided into three groups. The dogs in pacing group (n=5) and inhibitor group (n=5) were subjected to 3 weeks of rapid atrial pacing at 600 beats/min, control dogs (n=5) were in sham-operated group. The dogs in inhibitor group were administered intravenous N-Acetyl-Leu-Leu-Met (ALLM), a calpain inhibitor, and in pacing group and sham-operated group were administered intravenous DMSO. The activity of calpain I was measured by hydrolyzing Suc-Leu-Leu-Val-Tyr-7-amino-4-methyl-coumarin. The ultrastructure of atrium was examined by light and electron microscopy. TnT expression was assessed by Western blot. Echocardiography examination was performed in all the three groups. RESULTS: Calpain I activity was significantly increased in pacing group (2.3-fold, P<0.01), and decreased in inhibitor group (1.1-fold, P>0.05), compared to sham-operated group respectively. The percentages of myolysis were (76.7 +/- 5.9)% and (20.8 +/- 8.1)% in pacing group and inhibitor group respectively (P<0.01). TnT expression decreased in the rapid pacing-induced persistent atrial fibrillation, and these effects were inhibited by calpain I inhibitor ALLM. The area and volume of left atrium tended to increase after 3 weeks ALLM treatment in inhibitor group, but the change was not as prominent as in pacing group (P<0.05). CONCLUSIONS: ALLM can decrease calpain I activity, and prevent canine atrial cardiomyocyte structural remodeling during atrial fibrillation. This study provided a capacity of atrial cardiomyocyte protection.

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Publishing Authors By Initials

WM Li,HJ Xue,Y Li,L Zhang,YT Gong,L Sheng,S Chu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xin xue guan bing za zhi [Chinese journal

VOLUME: 35

Page Numbers: 132-6

Journal Abbreviation:

ISSN: 0253-3758

DAY: 20

MONTH: Feb

YEAR: 2007

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 7910682

[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]

AFFILIATION: Department of Cardiology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Xin Xue Guan Bing Za

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine Related Publications

• A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
• An image-based approach to measure the ferric ion diffusion coefficient in fricke gel dosimetry.
• Assays for nonhomologous end joining in extracts.
• Backpropagation Neural Network for Motion Analysis on Blood-pool Gated Single Photon Emission Computed Tomography.
• Determination of reaction intermediate structures in heme proteins.
• Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study.
• EUS could detect ascites missed by CT scan.
• Effects of growth factors on cell migration and alkaline phosphatase release.
• Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
• Familial resemblance of adiposity-related parameters: results from a health check-up population in Taiwan.
• Heterogeneous reactions of SO2 with HOCl and HOBr on ice surfaces.
• IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.
• MUC1, MUC2 and MUC5AC expressions in cardiac myxoma.
• Measuring the folding transition time of single RNA molecules.
• Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.
• PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
• Scale-up development of high-performance polymer matrix for DNA sequencing analysis.
• Synthesis of neplanocin F analogues as potential antiviral agents.
• Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.
• [Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]
• [Coronary artery atherosclerotic plaque and stent visualizations by optical coherence tomography]
• [Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients]
• [Dynamic changes and significance of serum TNF-alpha, IL-8 levels in patients with acute respiratory distress syndrome after severe trauma]
• [Irinotecan plus cisplatin for the treatment of advanced non-small cell lung cancer]
• [Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice]
• [Natural killer-like T-cell lymphoma/leukemia--a case report and literature review]
• [Phase I/II clinical trial of weekly administration of docetaxel plus cisplatin for advanced non-small cell lung cancer]
• [Polymorphism of HLA-DRB1 in Han population in Yunnan and comparison with 9 Han populations]
• [Risk factors for postoperative gastroparesis syndrome after pancreaticoduodenectomy with binary logistic regression.]
• [Visualization of intimal proliferation of drug-eluting stent and bare mental stent by use of optical coherence tomography]