Calmodulin: effects of cell stimuli and drugs on cellular activation.

Calmodulin: effects of cell stimuli and drugs on cellular activation. Research Abstract Details 

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Calmodulin: effects of cell stimuli and drugs on cellular activation. Abstract Text:

The activity, localization and cellular content of CaM can be regulated by drugs, hormones and neurotransmitters. Regulation of physiological responses of CaM can depend upon local Ca(2+)-entry domains in the cells and phosphorylation of CaM target proteins, which would either decrease responsiveness of CaM target enzymes or increase CaM availability for binding to other target proteins. Despite the abundance of CaM in many cells, persistent cellular activation by a variety of substances can lead to an increase in CaM, reflected both in the nucleus and other cellular compartments. Increases in CaM-binding proteins can accompany stimuli-induced increases in CaM. A role for CaM in vesicular or protein transport, cell morphology, secretion and other cytoskeletal processes is emerging through its binding to cytoskeletal proteins and myosins in addition to the more often investigated activation of target enzymes. More complete knowledge of the physiological regulation of CaM can lead to a greater understanding of its role in physiological processes and ways to alter its actions through pharmacology.

Calmodulin: effects of cell stimuli and drugs on cellular activation. Publishing Authors By Initials

For similar chemical and pharmacologic phenomena: stimulation, chemical research abstracts see: chemical and pharmacologic phenomena: stimulation, chemical research

PUBMED ID PMID:

MEDLINE DATE:

Calmodulin: effects of cell stimuli and drugs on cellular activation. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: 45

Page Numbers: 33-65

Journal Abbreviation:

ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 1995

Calmodulin: effects of cell stimuli and drugs on cellular activation. Information

Number of References: 248

LANGUAGE: eng

NlmUniqueID: 1304021

Calmodulin: effects of cell stimuli and drugs on cellular activation. Keywords Mesh Terms:

KEYWORDS: Stimulation, Chemical

MESH TERMS: metabolism

Chemical & Substance for Abstract: Calmodulin: effects of cell stimuli and drugs on cellular activation. Information

Substance Name: Calmodulin

Registry Number: 0

Grant and Affiliation Information for Calmodulin: effects of cell stimuli and drugs on cellular activation.

AFFILIATION: Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48103-0632, USA.

Country: SWITZERLAND

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MEDLINETA: Prog Drug Res

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