Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging.

Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Research Abstract Details 

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Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Abstract Text:

David C Isbell,Frederick H Epstein,Xiaodong Zhong,Joseph M DiMaria,Stuart S Berr,Craig H Meyer,Walter J Rogers,Nancy L Harthun,Klaus D Hagspiel,Arthur Weltman,Christopher M Kramer,

PURPOSE: To develop a contrast-enhanced magnetic resonance (MR) technique to measure skeletal muscle perfusion in peripheral arterial disease (PAD). MATERIALS AND METHODS: A total of 11 patients (age = 61 +/- 11 years) with mild to moderate symptomatic PAD (ankle-brachial index [ABI] = 0.75 +/- 0.08) and 22 normals were studied using an MR-compatible ergometer. PAD and normal(max) (Nl(max); N = 11) exercised to exhaustion. Nl(low) (N = 11) exercised to the same workload achieved by PAD. At peak exercise, 0.1 mm/kg of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) was infused at 3-4 cm(3)/second followed by a saline flush at the same rate. A dual-contrast gradient echo (GRE) sequence enabled simultaneous acquisition of muscle perfusion and arterial input function (AIF). The perfusion index (PI) was defined as the slope of the time-intensity curve (TIC) in muscle divided by the arterial TIC slope. RESULTS: Median workload was 120 Joules in PAD, 210 Joules in Nl(low), and 698 Joules in Nl(max) (P < 0.001 vs. Nl(low) and PAD). Median PI was 0.29 in PAD (25th and 75th percentiles [%] = 0.20, 0.40), 0.48 in Nl(low) (25th, 75th % = 0.36, 0.62; P < 0.02 vs. PAD), and 0.69 in Nl(max) (25th, 75th % = 0.5, 0.77; P < 0.001 vs. PAD). Area under the ROC-curve for PI differentiating patients from Nl(max) was 0.95 (95% confidence interval [CI] = 0.77-0.99). CONCLUSION: Peak-exercise measurement of lower limb perfusion with dual-contrast, first-pass MR distinguishes PAD from normals. This method may be useful in the study of novel therapies for PAD.

Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Publishing Authors By Initials

DC Isbell,FH Epstein,X Zhong,JM DiMaria,SS Berr,CH Meyer,WJ Rogers,NL Harthun,KD Hagspiel,A Weltman,CM Kramer,

For similar investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research

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Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 25

Page Numbers: 1013-20

Journal Abbreviation:

ISSN: 1053-1807

DAY: 3

MONTH: May

YEAR: 2007

Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9105850

Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Keywords Mesh Terms:

KEYWORDS: Statistics, Nonparametric

MESH TERMS: blood supply

Chemical & Substance for Abstract: Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging.

AFFILIATION: Department of Medicine, University of Virginia Health System, University of Virginia, Lee Street, Charlottesville, VA 22908, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL 075792

ACRONYM: HL

MEDLINETA: J Magn Reson Imaging

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