Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes.

Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Research Abstract Details 

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Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Abstract Text:

Anna Jankowska,Beata Burczynska,Teresa Duda,Jerzy B Warchol,Rameshwar K Sharma,

The importance of the second messengers, Ca(2+) and cyclic GMP, for the process of fertilization is well established; the mechanisms for their intracellular regulations in the testes are, however, poorly understood. This study documents the biochemical, molecular, and functional identity of a Ca(2+)-modulated membrane guanylate cyclase transduction machinery in bovine testes. The machinery is both inhibited and stimulated by free Ca(2+) levels. The Ca(2+)-sensor component of the inhibitory mode of the machinery is GCAP1 (guanylate cyclase activating protein type 1) and for the stimulatory mode is S100B. The transduction component is a Ca(2+)-driven rod outer segment membrane guanylate cyclase type 1, ROS-GC1. The cyclase is predominantly expressed in spermatogenic cells. GCAP1 expression is restricted to a small population of spermatogonia, whereas S100B is present in the majority of spermatocytes and spermatids. The expression of GCAP1 and S100B in spermatocytes and spermatids is mutually exclusive.

Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Publishing Authors By Initials

A Jankowska,B Burczynska,T Duda,JB Warchol,RK Sharma,

For similar urogenital system: genitalia: genitalia, male: testis research abstracts see: urogenital system: genitalia: genitalia, male: testis research

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Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of andrology

VOLUME: 28

Page Numbers: 50-8

Journal Abbreviation: J. Androl.

ISSN: 0196-3635

DAY: 23

MONTH: 08

YEAR: 2006

Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Information

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LANGUAGE: eng

NlmUniqueID: 8106453

Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Keywords Mesh Terms:

KEYWORDS: Testis

MESH TERMS: metabolism

Chemical & Substance for Abstract: Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes. Information

Substance Name: Guanylate Cyclase

Registry Number: EC 4.6.1.2

Grant and Affiliation Information for Calcium-modulated rod outer segment membrane guanylate cyclase type 1 transduction machinery in the testes.

AFFILIATION: Department of Cell Biology, University of Medical Sciences, Poznan, Poland. ajanko@amp.edu.pl

Country: United States

AGENCY: United States NHLBI

GRANT: HL 070015

ACRONYM: HL

MEDLINETA: J Androl

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