Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine.

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Abstract Text:

Wayne A Cass,Michael P Smith,Laura E Peters,

Repeated methamphetamine (METH) administration to animals can result in long-lasting decreases in brain dopamine (DA) and serotonin (5-HT) content. Calcitriol, the active metabolite of vitamin D, has potent effects on brain cells, both in vitro and in vivo, including the ability to upregulate trophic factors and protect against various lesions. The present experiments were designed to examine the ability of calcitriol to protect against METH-induced reductions in striatal and nucleus accumbens levels of DA and 5-HT. Male Fischer-344 rats were administered vehicle or calcitriol (1 microg/kg, s.c.) once a day for eight consecutive days. After the seventh day of treatment the animals were given METH (5 mg/kg, s.c.) or saline four times in 1 day at 2-h intervals. Seven days later the striata and accumbens were harvested from the animals for high-performance liquid chromatography (HPLC) analysis of monoamines and metabolites. In animals treated with vehicle and METH, there were significant reductions in DA, 5-HT, and their metabolites in both the striatum and accumbens. In animals treated with calcitriol and METH, the magnitude of the METH-induced reductions in DA, 5-HT, and metabolites was substantially and significantly attenuated. The calcitriol treatments did not reduce the hyperthermia associated with multiple injections of METH, indicating that the neuroprotective effects of calcitriol are not due to the prevention of increases in body temperature. These results suggest that calcitriol can provide significant protection against the DA- and 5-HT-depleting effects of neurotoxic doses of METH.

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Publishing Authors By Initials

WA Cass,MP Smith,LE Peters,

For similar organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research abstracts see: organic chemicals: amines: biogenic amines: biogenic monoamines: tryptamines: serotonin research

PUBMED ID PMID:

MEDLINE DATE:

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of the New York Academy of Sciences

VOLUME: 1074

Page Numbers: 261-71

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 3

MONTH: Aug

YEAR: 2006

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7506858

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Keywords Mesh Terms:

KEYWORDS: Serotonin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Information

Substance Name: Methamphetamine

Registry Number: 537-46-2

Grant and Affiliation Information for Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine.

AFFILIATION: Department of Anatomy and Neurobiology, MN-225 Chandler Medical Center, University of KY, Lexington, KY 40536-0298, USA. wacass1@uky.edu

Country: United States

AGENCY: United States NIDA

GRANT: DA10115

ACRONYM: DA

MEDLINETA: Ann N Y Acad Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine Related Publications

• A mouse TRAPP-related protein is involved in pigmentation.
• Assessment of the factors affecting the volume of fetally derived tissue in the bovine placentome.
• Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine.
• Catalytic receptors.
• Cell-surface transmitter transporters.
• Commentary left and right in classical Greece and Italy.
• Cooperative learning: a new application of problem-based learning in mental health training.
• De novo malignancies following liver transplantation: a case-control study with long-term follow-up.
• Determination of etoposide (VP16-213) and teniposide (VM-26) in serum by high-performance liquid chromatography with electrochemical detection.
• Dog ownership enhances symptomatic responses to air pollution in children with asthma.
• Fe(I)-mediated reductive cleavage and coupling of CO(2): an Fe(II)(mu-O, mu-CO)Fe(II) core.
• Functional characterization of the rice kaurene synthase-like gene family.
• Guide to Receptors and Channels, 2nd edition (2007 Revision).
• Immune epitope mapping in the post-genomic era: lessons for vaccine development.
• Long-term consequences of pain in human neonates.
• Nanoscopic medicine: the next frontier.
• Neuromodulation for the treatment of refractory interstitial cystitis.
• Novel model of antigen-specific induction of bile duct injury.
• Nuclear receptors.
• On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIV[triple bond]N, and related species.
• Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations.
• Prospective study of air pollution and bronchitic symptoms in children with asthma.
• Pseudotetrahedral manganese complexes supported by the anionic tris(phosphino)borate ligand [PhBP(iPr)3].
• Regular smoking and asthma incidence in adolescents.
• Separation of ribonucleotides, deoxynucleotides, cyclic nucleotides and deoxycyclic nucleotides by reversed-phase high-performance liquid chromatography.
• Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
• Skeletal muscle fiber type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression in fed and food-deprived rats.
• Synergistic inhibition of SARS-coronavirus replication by type I and type II IFN.
• The challenge of managing body weight in the modern world.
• Usefulness of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with a residual structural abnormality after definitive treatment for squamous cell carcinoma of the head and neck.