Calcineurin/Nfat signaling is required for perinatal lung maturation and function.

Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Research Abstract Details 

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Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Abstract Text:

Vrushank ,Tawanna Childs,Yan Xu,Machiko Ikegami, Besnard,Yutaka Maeda,Susan E Wert,Joel R Neilson,Gerald R Crabtree,Jeffrey A Whitsett,

Pulmonary surfactant proteins and lipids are required for lung function after birth. Lung immaturity and resultant surfactant deficiency cause respiratory distress syndrome, a common disorder contributing to morbidity and mortality in preterm infants. Surfactant synthesis increases prior to birth in association with formation of the alveoli that mediate efficient gas exchange. To identify mechanisms controlling perinatal lung maturation, the Calcineurin b1 (Cnb1) gene was deleted in the respiratory epithelium of the fetal mouse. Deletion of Cnb1 caused respiratory failure after birth and inhibited the structural maturation of the peripheral lung. Synthesis of surfactant and a lamellar body-associated protein, ABC transporter A3 (ABCA3), was decreased prior to birth. Nuclear factor of activated T cells (Nfat) calcineurin-dependent 3 (Nfatc3), a transcription factor modulated by calcineurin, was identified as a direct activator of Sftpa, Sftpb, Sftpc, Abca3, Foxa1, and Foxa2 genes. The calcineurin/Nfat pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.

Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Publishing Authors By Initials

V ,T Childs,Y Xu,M Ikegami,V Besnard,Y Maeda,SE Wert,JR Neilson,GR Crabtree,JA Whitsett,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical investigation

VOLUME: 116

Page Numbers: 2597-609

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 21

MONTH: 09

YEAR: 2006

Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802877

Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Information

Substance Name: Calcineurin

Registry Number: EC 3.1.3.-

Grant and Affiliation Information for Calcineurin/Nfat signaling is required for perinatal lung maturation and function.

AFFILIATION: Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. davev0@cchmc.org

Country: United States

AGENCY: United States NHLBI

GRANT: HL 56387

ACRONYM: HL

MEDLINETA: J Clin Invest

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