Caffeine as a potential indicator for acetylator status.

Caffeine as a potential indicator for acetylator status. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Caffeine as a potential indicator for acetylator status. Abstract Text:

The identification of patients as 'fast acetylators' or 'slow acetylators' is used in clinical practice to help recognize those at risk from toxicity and in guiding the dosage of N-acetylated drugs. Caffeine has been proposed as a marker for drug acetylation on the basis of a ratio of urinary metabolites (5-acetylamino-6-formylamino-3-methyl uracil and 1-methylxanthine, AFMU:MX) determined by high-performance liquid chromatography. The caffeine test was studied in 26 subjects by reference to the use of sulphamidine as the test substance. The distribution of urinary AFMU:MX ratios allowed assignment of subjects to 'slow' and 'fast' acetylator status (AFMU:MX less than 2.1 and greater than 2.3 respectively). The results showed accordance with those from the sulphadimidine test with the exception of one subject. The possible interference of concurrent administration of sulphadimidine (as an example of a drug known to undergo metabolism by N-acetylation) was also studied in 11 of the subjects. The interference was found to be small (apparent mean bias 11%) but of possible clinical significance.

Caffeine as a potential indicator for acetylator status. Publishing Authors By Initials

For similar heterocyclic compounds: alkaloids: xanthines research abstracts see: heterocyclic compounds: alkaloids: xanthines research

PUBMED ID PMID:

MEDLINE DATE:

Caffeine as a potential indicator for acetylator status. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 12

Page Numbers: 47-51

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Feb

YEAR: 1987

Caffeine as a potential indicator for acetylator status. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8704308

Caffeine as a potential indicator for acetylator status. Keywords Mesh Terms:

KEYWORDS: Xanthines

MESH TERMS: urine

Chemical & Substance for Abstract: Caffeine as a potential indicator for acetylator status. Information

Substance Name: Acetyltransferases

Registry Number: EC 2.3.1.-

Grant and Affiliation Information for Caffeine as a potential indicator for acetylator status.

AFFILIATION: Department of Pharmacy, Bangour General Hospital, West Lothian, U.K.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Clin Pharm Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Caffeine as a potential indicator for acetylator status Related Publications

• A simple method for assessing that internal doses are below action levels.
• Caffeine as a potential indicator for acetylator status.
• Challenges to be faced in the reconstruction of metabolic networks from public databases.
• Cognitive neurophysiology: beyond averaging.
• Editorial.
• Editorial.
• Enhancement of neocortical-medial temporal EEG correlations during non-REM sleep.
• HPLC studies on the degradation profiles of glucose 5% solutions subjected to heat sterilization in a microprocessor-controlled autoclave.
• Honor Bridget Fell: 22 May 1900-22 April 1986.
• Kwoniella mangroviensis gen. nov., sp. nov. (Tremellales, Basidiomycota), a teleomorphic yeast from mangrove habitats in the Florida Everglades and Bahamas.
• Luminex detection of fecal indicators in river samples, marine recreational water, and beach sand.
• Memory formation by refinement of neural representations: The inhibition hypothesis.
• Modular decomposition of metabolic systems via null-space analysis.
• Obituary notice.
• Observations on serum iron, zinc, copper and magnesium in intravenously fed patients with chronic sepsis.
• Postoperative leg vein thrombosis.
• Practical application of the Sports Medicine Australia pre-exercise screening system.
• Preparedness of residential and nursing homes for pandemic flu.
• Prevalence of yeasts in beach sand at three bathing beaches in South Florida.
• Preventing postoperative thrombosis.
• Reconstruction of (90)Sr intake for breast-fed infants in the Techa riverside settlements.
• Streptomycin intramuscular dosage per unit body weight correlated with serum levels in infants and children.
• Studies on abnormal metosis induced in chick tissue cultures by mustard gas (beta beta'-dichlordiethyl sulphide).
• The computation of ICRP dose coefficients for intakes of radionuclides with PLEIADES: biokinetic aspects.
• The effect of environmental temperature on protein and energy changes following burn injury in the rat.
• The effect of sympathectomy on the size of haversian canals in the cat.
• The influence of aluminium on parathyroid hormone levels in haemodialysis patients.
• The role of sleep in declarative memory consolidation--direct evidence by intracranial EEG.
• Treatment of prolapse in the elderly.
• Tricuspid atresia; report of two cases of young infants, with successful operation.