Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer.

Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Research Abstract Details 

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Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Abstract Text:

Shelley S Tworoger,Dorota M Gertig,Margaret A Gates,Jonathan L Hecht,Susan E Hankinson,

BACKGROUND: Smoking, caffeine, and alcohol intake are all potentially modifiable factors that have an unclear association with ovarian cancer risk. Therefore, the associations between these exposures and ovarian cancer risk were prospectively examined among 110,454 women in the Nurses' Health Study (NHS) for the smoking analyses and 80,253 women for the dietary analyses. METHODS: Women completed biennial questionnaires assessing ovarian cancer risk factors beginning in 1976, with food frequency questionnaires administered every 2 to 4 years starting in 1980. For the smoking analyses, 737 confirmed cases of epithelial ovarian cancer were identified and for the dietary aims, 507 cases were identified through June 1, 2004. RESULTS: Compared with never-smokers, neither current nor past smoking was associated with ovarian cancer risk overall; however, both were associated with mucinous tumors (n = 69; rate ratio [RR], past = 2.02 [95% confidence interval (CI), 1.15-3.55]; RR, current = 2.22 [95% CI, 1.16-4.24]). A modest inverse association between caffeine intake and ovarian cancer risk was observed (RR, top vs bottom quintile = 0.80; 95% CI, 0.60-1.07 [P = .03]), which was strongest for women who had never used either oral contraceptives (RR = 0.65; 95% CI, 0.46-0.92 [P for heterogeneity = .02]) or postmenopausal hormones (RR = 0.57; 95% CI, 0.36-0.91 [P for heterogeneity = .13]). Alcohol was not associated with ovarian cancer risk. CONCLUSIONS: The results of the current study suggest that cigarette smoking may only increase the risk for mucinous ovarian tumors, and alcohol intake was not associated with risk. However, an inverse association was observed between caffeine intake and ovarian cancer risk, particularly in women not using hormones; this finding merits further study. Cancer 2008. (c) 2008 American Cancer Society.

Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Publishing Authors By Initials

SS Tworoger,DM Gertig,MA Gates,JL Hecht,SE Hankinson,

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Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer

VOLUME: 112

Page Numbers: 1169-77

Journal Abbreviation: Cancer

ISSN: 0008-543X

DAY: 1

MONTH: Mar

YEAR: 2008

Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Information

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LANGUAGE: eng

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AFFILIATION: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Country: United States

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MEDLINETA: Cancer

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