Caenorhabditis elegans mutant allele identification by whole-genome sequencing.

Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Research Abstract Details 

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Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Abstract Text:

Identification of the molecular lesion in Caenorhabditis elegans mutants isolated through forward genetic screens usually involves time-consuming genetic mapping. We used Illumina deep sequencing technology to sequence a complete, mutant C. elegans genome and thus pinpointed a single-nucleotide mutation in the genome that affects a neuronal cell fate decision. This constitutes a proof-of-principle for using whole-genome sequencing to analyze C. elegans mutants.

Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Publishing Authors By Initials

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Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature methods

VOLUME: 5

Page Numbers: 865-7

Journal Abbreviation: Nat. Methods

ISSN: 1548-7105

DAY: 1

MONTH: 08

YEAR: 2008

Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Caenorhabditis elegans mutant allele identification by whole-genome sequencing.

AFFILIATION: Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, 701 W. 168th Street, New York, New York 10032, USA.

Country: United States

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MEDLINETA: Nat Methods

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