Cadherin-11 in synovial lining formation and pathology in arthritis.

Cadherin-11 in synovial lining formation and pathology in arthritis. Research Abstract Details 

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Cadherin-11 in synovial lining formation and pathology in arthritis. Abstract Text:

The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.

Cadherin-11 in synovial lining formation and pathology in arthritis. Publishing Authors By Initials

For similar musculoskeletal system: skeleton: joints: joint capsule: synovial membrane research abstracts see: musculoskeletal system: skeleton: joints: joint capsule: synovial membrane research

PUBMED ID PMID:

MEDLINE DATE:

Cadherin-11 in synovial lining formation and pathology in arthritis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 315

Page Numbers: 1006-10

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 25

MONTH: 01

YEAR: 2007

Cadherin-11 in synovial lining formation and pathology in arthritis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404511

Cadherin-11 in synovial lining formation and pathology in arthritis. Keywords Mesh Terms:

KEYWORDS: Synovial Membrane

MESH TERMS: pathology

Chemical & Substance for Abstract: Cadherin-11 in synovial lining formation and pathology in arthritis. Information

Substance Name: osteoblast cadherin

Registry Number: 156621-71-5

Grant and Affiliation Information for Cadherin-11 in synovial lining formation and pathology in arthritis.

AFFILIATION: Department of Medicine and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR48114

ACRONYM: AR

MEDLINETA: Science

REFSOURCE: Science. 2007 Feb 16;315(5814):952-3

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